The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing

Cheng Chen; Ziyu Meng; He Ren; Na Zhao; Ruoyu Shang; Weifeng He; Jianlei Hao

doi:10.1093/burnst/tkab009

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The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing

更新时间：2022-06-14

- The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing
- The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing
- Burns & Trauma 2021年9卷第1期
- 作者机构：
  
  1. State Key Laboratory of Trauma
  2. Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics
  3. NHC Key Laboratory of Hormones and Development
  4. Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University
  5. Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University
  6. Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University
  7. The Biomedical Translational Research Institute
  8. Jinan University
- 作者简介：
- 基金信息：
  
  This work was supported by grants from the General Program of National Natural Science Foundation of China (31872742 to WH, 31970830 and 81630025 to JH, 31800722 to ZM);the Military Medical Science and Technology Youth Cultivation Plan (20QNPY024);the Traditional Chinese Medicine Bureau of Guangdong Province (2018071 to JH);the Guangzhou Municipal Science and Technology Bureau (201904010090 to JH);the Health Commission of Guangdong Province (A2019520 to JH);and a grant from the Tianjin Natural Science Foundation (19JCQNJC11400 to ZM).
- DOI：10.1093/burnst/tkab009
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-6-23，
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Cheng Chen, Ziyu Meng, He Ren, 等. The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing[J]. Burns & Trauma, 2021,9(1).

Cheng Chen, Ziyu Meng, He Ren, Na Zhao, Ruoyu Shang, Weifeng He, Jianlei Hao, The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing, Burns & Trauma, Volume 9, 2021, tkab009, https://doi.org/10.1093/burnst/tkab009
Cheng Chen, Ziyu Meng, He Ren, 等. The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing[J]. Burns & Trauma, 2021,9(1). DOI： 10.1093/burnst/tkab009.

Cheng Chen, Ziyu Meng, He Ren, Na Zhao, Ruoyu Shang, Weifeng He, Jianlei Hao, The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing, Burns & Trauma, Volume 9, 2021, tkab009, https://doi.org/10.1093/burnst/tkab009 DOI：

摘要

Abstract

The epidermis is the outermost layer of skin and the first barrier against invasion. Dendritic epidermal T cells (DETCs) are a subset of γδ T cells and an important component of the epidermal immune microenvironment. DETCs are involved in skin wound healing

malignancy and autoimmune diseases. DETCs secrete insulin-like growth factor-1 and keratinocyte growth factor for skin homeostasis and re-epithelization and release inflammatory factors to adjust the inflammatory microenvironment of wound healing. Therefore

an understanding of their development

activation and correlative signalling pathways is indispensable for the regulation of DETCs to accelerate wound healing. Our review focuses on the above-mentioned molecular mechanisms to provide a general research framework to regulate and control the function of DETCs.

关键词

Keywords

Dendritic epidermal T cellsWound healingγδ T cellsCytokinesCytokine receptorsSignalling pathwaysskin

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