Mesenchymal stem cell-based therapy for burn wound healing

Mingyao Wang; Xinxuan Xu; Xiongxin Lei; Jie Tan; Huiqi Xie

doi:10.1093/burnst/tkab002

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Mesenchymal stem cell-based therapy for burn wound healing

更新时间：2022-06-14

- Mesenchymal stem cell-based therapy for burn wound healing
- Mesenchymal stem cell-based therapy for burn wound healing
- Burns & Trauma 2021年9卷第1期
- 作者机构：
  
  Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy
- 作者简介：
- 基金信息：
  
  This work was financially supported by the National Natural Science Foundation of China (Grant No. 31771065), Sichuan Provincial Science and Technology Program (Grant No. 2019JDRC0020), and the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (Grant No. ZYJC18002).
- DOI：10.1093/burnst/tkab002
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-5-1，
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Mingyao Wang, Xinxuan Xu, Xiongxin Lei, 等. Mesenchymal stem cell-based therapy for burn wound healing[J]. Burns & Trauma, 2021,9(1).

Mingyao Wang, Xinxuan Xu, Xiongxin Lei, Jie Tan, Huiqi Xie, Mesenchymal stem cell-based therapy for burn wound healing, Burns & Trauma, Volume 9, 2021, tkab002, https://doi.org/10.1093/burnst/tkab002
Mingyao Wang, Xinxuan Xu, Xiongxin Lei, 等. Mesenchymal stem cell-based therapy for burn wound healing[J]. Burns & Trauma, 2021,9(1). DOI： 10.1093/burnst/tkab002.

Mingyao Wang, Xinxuan Xu, Xiongxin Lei, Jie Tan, Huiqi Xie, Mesenchymal stem cell-based therapy for burn wound healing, Burns & Trauma, Volume 9, 2021, tkab002, https://doi.org/10.1093/burnst/tkab002 DOI：

摘要

Abstract

Burns

with their high incidence and mortality rates

have a devastating effect on patients. There are still huge challenges in the management of burns. Mesenchymal stem cells (MSCs)

which have multidirectional differentiation potential

have aroused interest in exploring the capacity for treating different intractable diseases due to their strong proliferation

tissue repair

immune tolerance and paracrine abilities

among other features. Currently

several animal studies have shown that MSCs play various roles and have beneficial effects in promoting wound healing

inhibiting burn inflammation and preventing the formation of pathological scars during burn healing process. The substances MSCs secrete can act on peripheral cells and promote burn repair. According to preclinical research

MSC-based treatments can effectively improve burn wound healing and reduce pain. However

due to the small number of patients and the lack of controls

treatment plans and evaluation criteria vary widely

thus limiting the value of these clinical studies. Therefore

to better evaluate the safety and effectiveness of MSC-based burn treatments

standardization of the application scheme and evaluation criteria of MSC therapy in burn treatment is required in the future. In addition

the combination of MSC pretreatment and dressing materials are also conducive to improving the therapeutic effect of MSCs on burns. In this article

we review current animal research and clinical trials based on the use of stem cell therapy for treating burns and discuss the main challenges and coping strategies facing future clinical applications.

关键词

Keywords

BurnWound healingStem cell-based therapyClinical trialRegenerative medicineProliferationTissue repairInflammation

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