A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns

Morgan Carlton; Joanne Voisey; Tony J Parker; Chamindie Punyadeera; Leila Cuttle

doi:10.1093/burnst/tkaa049

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A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns

更新时间：2022-06-14

- A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns
- A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns
- Burns & Trauma 2021年9卷第1期
- 作者机构：
  
  1. Queensland University of Technology (QUT), Centre for Children’s Burn and Trauma Research, Centre for Children’s Health Research
  2. Queensland University of Technology (QUT)
- 作者简介：
- 基金信息：
  
  Not applicable.
- DOI：10.1093/burnst/tkaa049
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-2-9，
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Morgan Carlton, Joanne Voisey, Tony J Parker, 等. A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns[J]. Burns & Trauma, 2021,9(1).

Morgan Carlton, Joanne Voisey, Tony J Parker, Chamindie Punyadeera, Leila Cuttle, A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns, Burns & Trauma, Volume 9, 2021, tkaa049, https://doi.org/10.1093/burnst/tkaa049
Morgan Carlton, Joanne Voisey, Tony J Parker, 等. A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns[J]. Burns & Trauma, 2021,9(1). DOI： 10.1093/burnst/tkaa049.

Morgan Carlton, Joanne Voisey, Tony J Parker, Chamindie Punyadeera, Leila Cuttle, A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns, Burns & Trauma, Volume 9, 2021, tkaa049, https://doi.org/10.1093/burnst/tkaa049 DOI：

摘要

Abstract

Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns. The objective of this review is to summarize the evidence supporting the use of biomarkers in children with burns. An extensive review of the literature was performed using PubMed. A total of 59 biomarkers were identified relating to burn presence

specifically relating to processes involved in inflammation

wound healing

growth and metabolism. In addition

biomarkers involved in the stress response cascade following a burn trauma were also identified. Although many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma

an understanding of burn biology is still lacking in children. We propose that future research in the field of children’s burns should be conducted using broad screening methods for identifying potential biomarkers

examine the biological interactions of different biomarkers

utilize child-appropriate biological fluids such as urine or saliva

and include a range of different severity burns. Through further research

the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed

for the improvement of healing outcomes in paediatric burn patients.

关键词

Keywords

Paediatric burnsBiomarkerInflammatoryHypothalamic-pituitary-adrenal axisPhysical traumaPsychological trauma

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