Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients

Lincoln M Tracy; Peter A Cameron; Yvonne Singer; Arul Earnest; Fiona Wood; Heather Cleland; Belinda J Gabbe

doi:10.1093/burnst/tkaa044

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Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients

更新时间：2022-06-14

- Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients
- Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients
- Burns & Trauma 2021年9卷第1期
- 作者机构：
  
  1. School of Public Health and Preventive Medicine, Monash University
  2. Emergency and Trauma Centre, The Alfred Hospital
  3. Victorian Adult Burns Service
  4. Registry Sciences Unit
  5. Monash University
  6. Biostatistics Unit
  7. Burn Injury Research Unit, University of Western Australia
  8. Health Data Research UK, Swansea University Medical School
- 作者简介：
- 基金信息：
  
  The registry has received funding from the Australian and New Zealand Burn Association;the Australian Commission on Safety and Quality in Health Care (2008–2009);the Julian Burton Burns Trust (2008–2013);the Helen Macpherson Smith Trust (2010–2012);the Thyne Reid Foundation (2011–2013);the Australasian Foundation for Plastic Surgery (2013–2017);the New Zealand Accident Compensation Corporation (2013–2020);the Clipsal by Schnieder Electric National Community Grants Program (2017);and the HCF Research Foundation (2018–2019). Individual burns units also contribute funding to the registry to ensure its ongoing sustainability. BJG was supported by an Australian Research Council Future Fellowship (FT170100048) during the preparation of this manuscript.
- DOI：10.1093/burnst/tkaa044
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-2-11，
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Lincoln M Tracy, Peter A Cameron, Yvonne Singer, 等. Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients[J]. Burns & Trauma, 2021,9(1).

Lincoln M Tracy, Peter A Cameron, Yvonne Singer, Arul Earnest, Fiona Wood, Heather Cleland, Belinda J Gabbe, Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients, Burns & Trauma, Volume 9, 2021, tkaa044, https://doi.org/10.1093/burnst/tkaa044
Lincoln M Tracy, Peter A Cameron, Yvonne Singer, 等. Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients[J]. Burns & Trauma, 2021,9(1). DOI： 10.1093/burnst/tkaa044.

Lincoln M Tracy, Peter A Cameron, Yvonne Singer, Arul Earnest, Fiona Wood, Heather Cleland, Belinda J Gabbe, Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients, Burns & Trauma, Volume 9, 2021, tkaa044, https://doi.org/10.1093/burnst/tkaa044 DOI：

摘要

Abstract

BackgroundPatients with burn injuries are considered to have an increased risk of venous thromboembolism (VTE). While untreated VTEs can be fatal

no studies have examined chemoprophylaxis effectiveness. This study aimed to quantify the variation in prevalence of VTE prophylaxis use in patients in Australian and New Zealand burns units and whether prophylaxis use is associated with in-hospital outcomes following burn injury.MethodsAdmission data for adult burns patients (aged ≥16 years) admitted between 1 July 2016 and 31 December 2018 were extracted from the Burns Registry of Australia and New Zealand. Mixed effects logistic regression modelling investigated whether VTE prophylaxis use was associated with the primary outcome of in-hospital mortality.ResultsThere were 5066 admissions over the study period. Of these patients

81% (n = 3799) with a valid response to the VTE prophylaxis data field received some form of VTE prophylaxis. Use of VTE prophylaxis ranged from 48.6% to 94.8% of patients between units. In-hospital death was recorded in <1% of patients (n = 33). After adjusting for confounders

receiving VTE prophylaxis was associated with a decrease in the adjusted odds of in-hospital mortality (adjusted odds ratio = 0.21; 95% CI

0.07–0.63; p = 0.006).ConclusionsVariation in the use of VTE prophylaxis was observed between the units

and prophylaxis use was associated with a decrease in the odds of mortality. These findings provide an opportunity to engage with units to further explore differences in prophylaxis use and develop future best practice guidelines.

关键词

Keywords

Burn injuryVenous thromboembolismProphylaxisAustraliaNew Zealand

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