Microbiome in the setting of burn patients: implications for infections and clinical outcomes

Silvia Corcione; Tommaso Lupia; Francesco G De Rosa; Host and Microbiota Interaction Study Group (ESGHAMI) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)

doi:10.1093/burnst/tkaa033

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Microbiome in the setting of burn patients: implications for infections and clinical outcomes

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- Microbiome in the setting of burn patients: implications for infections and clinical outcomes
- Microbiome in the setting of burn patients: implications for infections and clinical outcomes
- Burns & Trauma 2020年8卷第1期
- 作者机构：
  
  1. Department of Medical Sciences
  2. University of Turin
  3. Tufts University School of Medicine
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkaa033
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-8-14，
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Silvia Corcione, Tommaso Lupia, Francesco G De Rosa, 等. Microbiome in the setting of burn patients: implications for infections and clinical outcomes[J]. Burns & Trauma, 2020,8(1).

Silvia Corcione, Tommaso Lupia, Francesco G De Rosa, Host and Microbiota Interaction Study Group (ESGHAMI) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Microbiome in the setting of burn patients: implications for infections and clinical outcomes, Burns & Trauma, Volume 8, 2020, tkaa033, https://doi.org/10.1093/burnst/tkaa033
Silvia Corcione, Tommaso Lupia, Francesco G De Rosa, 等. Microbiome in the setting of burn patients: implications for infections and clinical outcomes[J]. Burns & Trauma, 2020,8(1). DOI： 10.1093/burnst/tkaa033.

Silvia Corcione, Tommaso Lupia, Francesco G De Rosa, Host and Microbiota Interaction Study Group (ESGHAMI) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Microbiome in the setting of burn patients: implications for infections and clinical outcomes, Burns & Trauma, Volume 8, 2020, tkaa033, https://doi.org/10.1093/burnst/tkaa033 DOI：

摘要

Abstract

Burn damage can lead to a state of immune dysregulation that facilitates the development of infections in patients. The most deleterious impact of this dysfunction is the loss of the skin’s natural protective barrier. Furthermore

the risk of infection is exacerbated by protracted hospitalization

urinary catheters

endotracheal intubation

inhalation injury

arterial lines and central venous access

among other mainstays of burn care. Currently

infections comprise the leading cause of mortality after major burn injuries

which highlights the improvements observed over the last 50 years in the care provided to burn victims. The need to implement the empirical selection of antibiotic therapy to treat multidrug-resistant bacteria may concomitantly lead to an overall pervasiveness of difficult-to-treat pathogens in burn centres

as well as the propagation of antimicrobial resistance and the ultimate dysregulation of a healthy microbiome. While preliminary studies are examining the variability and evolution of human and mice microbiota

both during the early and late phase burn injury

one must consider that abnormal microbiome conditions could influence the systemic inflammatory response. A better understanding of the changes in the post-burn microbiome might be useful to interpret the provenance and subsequent development of infections

as well as to come up with inferences on the prognosis of burn patients. This review aims to summarise the current findings describing the microbiological changes in different organs and systems of burn patients and how these alterations affect the risks of infections

complications

and

ultimately

healing.

关键词

Keywords

BurnMicrobiomeSkin microbiomeGut microbiomeLung microbiomeMultidrug-resistant organisms

references

1.Norbury W, Herndon DN, Tanksley J, Jeschke MG, Finnerty CC. Infection in burns. Surg Infect (Larchmt). 2016; 17(2): 250–5. doi: 10.1089/sur.2013.134.

2.Lachiewicz AM, Hauck CG, Weber DJ, Cairns BA, van Duin D. Bacterial infections after burn injuries: impact of multidrug resistance. Clin Infect Dis. 2017; 65(12): 2130–6. doi: 10.1093/cid/cix682.

3.MacConmara MP, Tajima G, O'Leary F, Delisle AJ, McKenna AM, Stallwood CG, et al. Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. J Leukoc Biol. 2011; 89(1): 137–47. doi: 10.1189/jlb.0210082. Epub 2010 Sep 30.

4.Magnotti LJ, Deitch EA. Burns, bacterial translocation, gut barrier function, and failure. J Burn Care Rehabil. 2005; 26(5): 383–91.

5.Beckmann N, Pugh AM, Caldwell CC. Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression. PLoS One. 2018; 13(10): e0205307. doi: 10.1371/journal.pone.0205307. eCollection 2018.

6.Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, et al. Burn injury alters the intestinal microbiome and increases gut permeability and bacterial translocation. PLoS One. 2015; 10(7): e0129996. doi: 10.1371/journal.pone.0129996. eCollection 2015.

7.Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, et al. Metagenomic analysis of the human distal gut microbiome. Science. 2006;312(5778):1355–9. doi: 10.1126/science.1124234. PMID: 16741115; PMCID: PMC3027896.

8.Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007; 449(7164): 804–10.

9.van Duin D, Strassle PD, DiBiase LM, Lachiewicz AM, Rutala WA, Eitas T, et al. Timeline of health care-associated infections and pathogens after burn injuries. Am J Infect Control. 2016;44(12):1511–6. doi: 10.1016/j.ajic.2016.07.027. Epub 2016 Oct 11.

10.Wanis M, Walker SAN, Daneman N, Elligsen M, Palmay L, Simor A, et al. Impact of hospital length of stay on the distribution of gram negative bacteria and likelihood of isolating a resistant organism in a Canadian burn center. Burns. 2016; 42(1): 104–11. doi: 10.1016/j.burns.2015.07.010 Epub 2015 Nov 5.

11.Alp E, Coruh A, Gunay GK, Yontar Y, Doganay M. Risk factors for nosocomial infection and mortality in burn patients: 10 years of experience at a university hospital. J Burn Care Res. 2012; 33(3): 379–85. doi: 10.1097/BCR.0b013e318234966c.

12.Strassle PD, Williams FN, Weber DJ, Sickbert-Bennett EE, Lachiewicz AM, Napravnik S, et al. Risk factors for healthcare-associated infections in adult burn patients. Infect Control Hosp Epidemiol. 2017; 38(12): 1441–8. doi: 10.1017/ice.2017.220. Epub 2017 Oct 30.

13.Rezaei E, Safari H, Naderinasab M, Aliakbarian H. Common pathogens in burn wound and changes in their drug sensitivity. Burns. 2011; 37(5): 805–7. doi: 10.1016/j.burns.2011.01.019 Epub 2011 Mar 8.

14.Sun FJ, Zhang XB, Fang Y, Chen J, Xing H, Shi H, et al. Spectrum and drug resistance of pathogens from patients with burns. Burns. 2012; 38(8): 1124–30. doi: 10.1016/j.burns.2012.05.018.

15.Messadi AA, Lamia T, Kamel B, Salima O, Monia M, Saida BR. Association between antibiotic use and changes in susceptibility patterns of Pseudomonas aeruginosa in an intensive care burn unit: a 5-year study, 2000-2004. Burns 2008; 34(8): 1098–102. doi: 10.1016/j.burns.2008.03.014.

16.Moiemen NS; ISBI guideline committee. Antibiotic stewardship in burns patients: ISBI guidelines. Burns. 2017;43(6):1366. doi: 10.1016/j.burns.2016.12.009. Epub 2017 Jun 19. No abstract available.

17.Lavrentieva A. Antibiotic stewardship in burn patients: from theory to reality and vice versa. Burns. 2017; 43(6): 1364–6. doi: 10.1016/j.burns.2016.11.018 Epub 2017 Feb 4.

18.Taur Y, Pamer EG. The intestinal microbiota and susceptibility to infection in immunocompromised patients. Curr Opin Infect Dis. 2013; 26(4): 332–7. doi: 10.1097/QCO.0b013e3283630dd3.

19.Satlin MJ, Jenkins SG, Walsh TJ. The global challenge of carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancies. Clin Infect Dis. 2014; 58(9): 1274–83. doi: 10.1093/cid/ciu052. Epub 2014 Jan 23.

20.Kim S, Covington A, Pamer EG. The intestinal microbiota: antibiotics, colonization resistance, and enteric pathogens. Immunol Rev. 2017; 279(1): 90–105. doi: 10.1111/imr.12563 Review.

21.Corcione S, Angilletta R, Raviolo S, Filippini C, Fossati L, Di Perri G, et al. Epidemiology and risk factors for mortality in bloodstream infection by CP-Kp, ESBL-E, Candida and CDI: a single center retrospective study. Eur J Intern Med. 2018; 48: 44–9. doi: 10.1016/j.ejim.2017.10.015 Epub 2017 Oct 31.

22.Corcione S, Segala FV, Castiglione A, Lupia T, Angilletta R, Cavallo R, et al. Enteropathogenetic nosocomial infections: predisposing clinical characteristics and risk of recurrent infections. J Chemother. 2019; 31(7–8): 394–400. doi: 10.1080/1120009X.2019.1669275 Epub 2019 Sep 26.

23.Wheatley EG, Curtis BJ, Hulsebus HJ, Boe DM, Najarro K, Ir D, et al. Advanced age impairs intestinal antimicrobial peptide response and worsens Fecal microbiome Dysbiosis following burn injury in mice. Shock. 2020; 53(1): 71–7. doi: 10.1097/SHK.0000000000001321.

24.He W, Wang Y, Wang P, Wang F. Intestinal barrier dysfunction in severe burn injury. Burns Trauma. 2019; 7: 24. doi: 10.1186/s41038-019-0162-3. eCollection 2019

25.Barrett LW, Fear VS, Waithman JC, Wood FM, Fear MW. Understanding acute burn injury as a chronic disease. Burns Trauma. 2019; 7: 23. doi: 10.1186/s41038-019-0163-2. eCollection 2019

26.Al-Ghoul WM, Khan M, Fazal N, Sayeed MM. Mechanisms of postburn intestinal barrier dysfunction in the rat: roles of epithelial cell renewal, E-cadherin, and neutrophil extravasation. Crit Care Med. 2004; 32(8): 1730–9.

27.De-Souza DA, Greene LJ. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Crit Care Med. 2005; 33(5): 1125–35 Review.

28.Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009; 9(11): 799–809. doi: 10.1038/nri2653 Review.

29.Xiao GX. The gut-origin infection in severe bums. Chin J Burns. 2008; 24(5): 331–3.

30.Costantini TW, Eliceiri BP, Peterson CY, Loomis WH, Putnam JG, Baird A, et al. Quantitative assessment of intestinal injury using a novel in vivo, near-infrared imaging technique. Mol Imaging. 2010; 9(1): 30–9.

31.Costantini TW, Loomis WH, Putnam JG, Kroll L, Eliceiri BP, Baird A, et al. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009; 66(1): 17–24discussion 24-5. doi: 10.1097/TA.0b013e318191bb1f.

32.Huang G, Sun K, Yin S, Jiang B, Chen Y, Gong Y, et al. Burn injury leads to increase in relative abundance of opportunistic pathogens in the rat gastrointestinal microbiome. Front Microbiol. 2017; 8: 1237. doi: 10.3389/fmicb.2017.01237. eCollection 2017.

33.Cushing K, Alvarado DM, Ciorba MA. Butyrate and mucosal inflammation: new scientific evidence supports clinical observation. Clin Transl Gastroenterol. 2015; 6: e108. doi: 10.1038/ctg.2015.34.

34.Feng Y, Huang Y, Wang Y, Wang P, Wang F. Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice. Burns Trauma. 2019; 7(20). doi: 10.1186/s41038-019-0156-1. eCollection 2019

35.Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes. 2016; 7(3): 189–200. doi: 10.1080/19490976.2015.1134082. Epub 2016 Mar 10.

36.Zhang D, Zhu C, Fang Z, Zhang H, Yang J, Tao K, et al. Remodeling gut microbiota by clostridium butyricum (C.butyricum) attenuates intestinal injury in burned mice. Burns. 2020pii: S0305-4179(19)30641-2. doi: 10.1016/j.burns.2020.01.007 [Epub ahead of print].

37.Shimizu K, Ogura H, Asahara T, Nomoto K, Matsushima A, Hayakawa K, et al. Gut microbiota and environment in patients with major burns – a preliminary report. Burns 2015; 41(3): e28–33. doi: 10.1016/j.burns.2014.10.019 Epub 2014 Nov 30.

38.Wang X, Yang J, Tian F, Zhang L, Lei Q, Jiang T, et al. Gut microbiota trajectory in patients with severe burn: a time series study. J Crit Care. 2017; 42: 310–6. doi: 10.1016/j.jcrc.2017.08.020 Epub 2017 Aug 12.

39.McIntyre MK, Winkler CJ, Gómez BI, Lapierre JP, Little JS, Dubick MA, et al. The effect of burn resuscitation volumes on the gut microbiome in a swine model. Shock. 2019. doi: 10.1097/SHK.0000000000001462 Epub ahead of print.

40.Palmieri TL. Inhalation injury: research progress and needs. J Burn Care Res. 2007; 28(4): 549–54.

41.You K, Yang HT, Kym D, Yoon J, Yim H, Cho YS, et al. Inhalation injury in burn patients: establishing the link between diagnosis and prognosis. Burns. 2014; 40(8): 1470–5. doi: 10.1016/j.burns.2014.09.015 Epub 2014 Oct 16.

42.Dyamenahalli K, Garg G, Shupp JW, Kuprys PV, Choudhry MA, Kovacs EJ. Inhalation injury: unmet clinical needs and future research. J Burn Care Res. 2019; 40(5): 570–84. doi: 10.1093/jbcr/irz055.

43.Walsh DM, Mccullough SD, Yourstone S, Jones SW, Cairns A, Jones CD, et al. Alterations in airway microbiota in patients with PaO 2 / FiO 2 ratio 300 after burn and inhalation injury. PLoS One 2017; 12(3): e0173848. doi: 10.1371/journal.pone.0173848 eCollection 2017.

44.The ARDS Task Force. Acute respiratory distress syndrome: the berlin definition. JAMA. 2012; 307(23): 2526–33. doi: 10.1001/jama.2012.5669.

45.Buckingham SC. Bacteroides, Fusobacterium, and Prevotella. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ (eds). Feigin and Cherry’s Textbook of Pediatric Infectious Diseases, Seventh edn, 2014, 1825–34.

46.Agvald-Ohman C, Wernerman J, Nord CE, Edlund C. Anaerobic bacteria commonly colonize the lower airways of intubated ICU patients. Clin Microbiol Infect. 2003; 9(5): 397–405.

47.Field TR, Sibley CD, Parkins MD, Rabin HR, Surette MG. The genus Prevotella in cystic fibrosis airways. Anaerobe. 2010; 16(4): 337–44. doi: 10.1016/j.anaerobe.2010.04.002 Epub 2010 Apr 20.

48.Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011; 9(4): 244–53. doi: 10.1038/nrmicro2537.

49.Chehoud C, Rafail S, Tyldsley AS, Seykora JT, Lambris JD, Grice EA. Complement modulates the cutaneous microbiome and inflammatory milieu. Proc Natl Acad Sci U S A. 2013; 110(37): 15061–6. doi: 10.1073/pnas.1307855110. Epub 2013 Aug 26.

50.Grice EA. The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease. Semin Cutan Med Surg. 2014; 33(2): 98–103.

51.Plichta JK, Gao X, Lin H, Dong Q, Toh E, Nelson DE, et al. Cutaneous burn injury promotes shifts in the bacterial microbiome in autologous donor skin: implications for skin grafting outcomes. Shock. 2017; 48(4): 441–8. doi: 10.1097/SHK.0000000000000874.

52.Schauber J, Dorschner RA, Coda AB, Buchau AS, Liu PT, Kiken D, et al. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest. 2007; 117(3): 803–11 Epub 2007 Feb 8.

53.Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, et al. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009; 106(31): 12873–8. doi: 10.1073/pnas.0904958106. Epub 2009 Jun 16.

54.Lai Y, Cogen AL, Radek KA, Park HJ, Macleod DT, Leichtle A, et al. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol. 2010; 130(9): 2211–21. doi: 10.1038/jid.2010.123. Epub 2010 May 13.

55.Li WJ, Zhang YQ, Schumann P, Liu HY, Yu LY, Zhang YQ, et al. Nesterenkonia halophila sp. nov., a moderately halophilic, alkalitolerant actinobacterium isolated from a saline soil. Int J Syst Evol Microbiol. 2008;58(Pt 6):1359–63. doi: 10.1099/ijs.0.64226-0

56.Zhao W, Zhang CL, Romanek CS, Wiegel J. Description of Caldalkalibacillus uzonensis sp. nov. and emended description of the genus Caldalkalibacillus. Int J Syst Evol Microbiol. 2008; 58(Pt 5):1106–8.

57.Minana-Galbis D, Pinzon DL, Loren JG, Manresa A, Oliart-Ros RM. Reclassification of Geobacillus pallidus (Scholz et al. 1988) Banat et al. 2004 as Aeribacillus pallidus gen. Nov., comb. nov. Int J Syst Evol Microbiol. 2010; 60(Pt 7): 1600–4. doi: 10.1099/ijs.0.003699-0 Epub 2009 Aug 21.

58.Liu SH, Huang YC, Chen LY, Yu SC, Yu HY, Chuang SS. The skin microbiome of wound scars and unaffected skin in patients with moderate to severe burns in the subacute phase. Wound Repair Regen. 2018; 26(2): 182–91. doi: 10.1111/wrr.12632. Epub 2018 May 21.

59.Dethlefsen L, Huse S, Sogin ML, Relman DA. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol. 2008; 6(11): e280. doi: 10.1371/journal.pbio.0060280.

60.Raymond F, Ouameur AA, Déraspe M, Iqbal N, Gingras H, Dridi B, et al. The initial state of the human gut microbiome determines its reshaping by antibiotics. ISME J. 2016; 10(3): 707–20. doi: 10.1038/ismej.2015.148. Epub 2015 Sep 11.

61.Sanjar F, Weaver AJ, Peacock TJ, Nguyen JQ, Brandenburg KS, Leung KP. Identification of Metagenomics structure and function associated with temporal changes in rat (Rattus norvegicus) skin microbiome during health and cutaneous burn. J Burn Care Res. 2020; 41(2): 347–58. doi: 10.1093/jbcr/irz165

62.Johnson TR, Gómez BI, McIntyre MK, Dubick MA, Christy RJ, Nicholson SE, et al. The cutaneous microbiome and wounds: new molecular targets to promote wound healing. Int J Mol Sci 2018; 19(9) pii: E2699. doi: 10.3390/ijms19092699.

63.Corcione S, Pensa A, Castiglione A, Lupia T, Bortolaso B, Romeo MR, et al. Epidemiology, prevalence and risk factors for infections in burn patients: results from a regional burn centre's analysis [published online ahead of print, 2020 Jun 26]. J Chemother. 2020; 1–5. doi: 10.1080/1120009X.2020.1780776.

64.Lin JC, Chen ZH, Chen XD. Elevated serum procalcitonin predicts gram-negative bloodstream infections in patients with burns. Burns. 2020; 46(1): 182–9. doi: 10.1016/j.burns.2019.04.010 Epub 2019 Dec 16.

65.Corcione S, D'Avolio A, Loia RC, Pensa A, Segala FV, De Nicolò A, et al. Pharmacokinetics of meropenem in burn patients with infections caused by gram-negative bacteria: are we getting close to the right treatment? J Glob Antimicrob Resist. 2020; 20: 22–7. doi: 10.1016/j.jgar.2019.06.011 Epub 2019 Jun 14.

66.Corcione S, Pagani N, Forni N, Di Perri G, De Rosa FG. Start smart with antimicrobial stewardship. Clin Infect Dis 2015; 61(6): 1033–4. doi: 10.1093/cid/civ458 Epub 2015 Jun 10. No abstract available.

67.Bassetti M, Poulakou G, Ruppe E, Bouza E, Van Hal SJ, Brink A. Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach. Intensive Care Med 2017;43(10):1464–75. doi: 10.1007/s00134-017-4878-x. Epub 2017 Jul 21.

68.Zhang M, Jiang Z, Li D, Jiang D, Wu Y, Ren H, et al. Oral antibiotic treatment induces skin microbiota dysbiosis and influences wound healing. Microb Ecol 2015; 69: 415–21.

69.Canesso MC, Vieira AT, Castro TB, Schirmer BG, Cisalpino D, Martins FS, et al. Skin wound healing is accelerated and scarless in the absence of commensal microbiota. J Immunol 2014; 193: 5171–80.

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