Vascularization is the next challenge for skin tissue engineering as a solution for burn management

Hady Shahin; Moustafa Elmasry; Ingrid Steinvall; Folke Söberg; Ahmed El-Serafi

doi:10.1093/burnst/tkaa022

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Vascularization is the next challenge for skin tissue engineering as a solution for burn management

更新时间：2022-06-09

- Vascularization is the next challenge for skin tissue engineering as a solution for burn management
- Vascularization is the next challenge for skin tissue engineering as a solution for burn management
- Burns & Trauma 2020年8卷第1期
- 作者机构：
  
  1. Department of Hand Surgery and Plastic Surgery and Burns
  2. The Department of Biomedical and Clinical Sciences
  3. Faculty of Biotechnology
- 作者简介：
- 基金信息：
  
  Not applicable.
- DOI：10.1093/burnst/tkaa022
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-8-3，
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Hady Shahin, Moustafa Elmasry, Ingrid Steinvall, 等. Vascularization is the next challenge for skin tissue engineering as a solution for burn management[J]. Burns & Trauma, 2020,8(1).

Hady Shahin, Moustafa Elmasry, Ingrid Steinvall, Folke Söberg, Ahmed El-Serafi, Vascularization is the next challenge for skin tissue engineering as a solution for burn management, Burns & Trauma, Volume 8, 2020, tkaa022, https://doi.org/10.1093/burnst/tkaa022
Hady Shahin, Moustafa Elmasry, Ingrid Steinvall, 等. Vascularization is the next challenge for skin tissue engineering as a solution for burn management[J]. Burns & Trauma, 2020,8(1). DOI： 10.1093/burnst/tkaa022.

Hady Shahin, Moustafa Elmasry, Ingrid Steinvall, Folke Söberg, Ahmed El-Serafi, Vascularization is the next challenge for skin tissue engineering as a solution for burn management, Burns & Trauma, Volume 8, 2020, tkaa022, https://doi.org/10.1093/burnst/tkaa022 DOI：

摘要

Abstract

Skin regeneration represents a promising line of management for patients with skin loss

including burn victims. The current approach of spraying single cells over the defective areas results in variable success rates in different centers. The modern approach is to synthesize a multilayer skin construct that is based on autologous stem cells. One of the main complications with different types of transplants is sloughing due to the absence of proper vascularization. Ensuring proper vascularization will be crucial for the integration of skin constructs with the surrounding tissues. Combination of the right cells with scaffolds of proper physico-chemical properties

vascularization can be markedly enhanced. The material effect

pore size and adsorption of certain proteins

as well as the application of appropriate growth factors

such as vascular endothelial growth factors

can have an additive effect. A selection of the most effective protocols is discussed in this review.

关键词

Keywords

BurnskinRegenerationTissue engineeringVascularization

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