A modified scar model with controlled tension on secondary wound healing in mice

Zi Wang; Xin Huang; Tao Zan; Qingfeng Li; Haizhou Li

doi:10.1093/burnst/tkaa013

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A modified scar model with controlled tension on secondary wound healing in mice

更新时间：2022-06-09

- A modified scar model with controlled tension on secondary wound healing in mice
- A modified scar model with controlled tension on secondary wound healing in mice
- Burns & Trauma 2020年8卷第1期
- 作者机构：
  
  Department of Plastic and Reconstructive Surgery
- 作者简介：
- 基金信息：
  
  This work was supported by grants from the National Natural Science Foundation of China (81501668).
- DOI：10.1093/burnst/tkaa013
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-5-6，
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Zi Wang, Xin Huang, Tao Zan, 等. A modified scar model with controlled tension on secondary wound healing in mice[J]. Burns & Trauma, 2020,8(1).

Zi Wang, Xin Huang, Tao Zan, Qingfeng Li, Haizhou Li, A modified scar model with controlled tension on secondary wound healing in mice, Burns & Trauma, Volume 8, 2020, tkaa013, https://doi.org/10.1093/burnst/tkaa013
Zi Wang, Xin Huang, Tao Zan, 等. A modified scar model with controlled tension on secondary wound healing in mice[J]. Burns & Trauma, 2020,8(1). DOI： 10.1093/burnst/tkaa013.

Zi Wang, Xin Huang, Tao Zan, Qingfeng Li, Haizhou Li, A modified scar model with controlled tension on secondary wound healing in mice, Burns & Trauma, Volume 8, 2020, tkaa013, https://doi.org/10.1093/burnst/tkaa013 DOI：

摘要

Abstract

Pathological scars might cause a distorted appearance and restricted mobility

and the study of scar pathophysiology has been hindered by the absence of a reliable model. In this study

we introduce a model with a modified device to induce controlled tension on a wound healing by secondary intention to overcome the shortcomings of the model generated by Aarabi et al. We investigated and recommend an induction of 0.1 N/mm2 tension on day 7 for 14 days to mimic the characteristics of human scars. A 3.5-fold increase in scar tissue and a 2-fold increase in collagen production were induced by the modified model. Histologically

the modified method increased scar thickness. However

no significant difference was found in cell density between the two groups. This modified procedure significantly increased scar tissue

which could be used for further cellular and biomolecular research. The mechanical force applied to the wound became measurable and controllable. This method is more convenient for researchers to observe in real-time and for providing timely adjustments of the tension used in this modified model.

关键词

Keywords

Scar modelMechanical forceMurine modelWound healing

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