The role of macrophages in the formation of hypertrophic scars and keloids

Xiangwen Xu; Shuchen Gu; Xin Huang; Jieyi Ren; Yihui Gu; Chengjiang Wei; Xiang Lian; Haizhou Li; Yashan Gao; Rui Jin; Bin Gu; Tao Zan; Zhichao Wang

doi:10.1093/burnst/tkaa006

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The role of macrophages in the formation of hypertrophic scars and keloids

更新时间：2022-06-09

- The role of macrophages in the formation of hypertrophic scars and keloids
- The role of macrophages in the formation of hypertrophic scars and keloids
- Burns & Trauma 2020年8卷第1期
- 作者机构：
  
  Department of Plastic and Reconstructive Surgery
- 作者简介：
- 基金信息：
  
  This work was supported by grants from the Youth Doctor Collaborative Innovation Team Project (QC201803) of Shanghai Ninth People’s Hospital;the Shanghai Jiaotong University School of Medicine;the Shanghai Youth Top-Notch Talent Program (for ZW);the National Natural Science Foundation of China (81772086, 81701901);the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant (20161424);Shanghai “Rising Stars of Medical Talent” Youth Development Program (Outstanding Youth Medical Talents);and the Shanghai Jiaotong University “Chenxing” Youth Development Program (Associate Professor Type A).
- DOI：10.1093/burnst/tkaa006
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-3-11，
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Xiangwen Xu, Shuchen Gu, Xin Huang, 等. The role of macrophages in the formation of hypertrophic scars and keloids[J]. Burns & Trauma, 2020,8(1).

Xiangwen Xu, Shuchen Gu, Xin Huang, Jieyi Ren, Yihui Gu, Chengjiang Wei, Xiang Lian, Haizhou Li, Yashan Gao, Rui Jin, Bin Gu, Tao Zan, Zhichao Wang, The role of macrophages in the formation of hypertrophic scars and keloids, Burns & Trauma, Volume 8, 2020, tkaa006, https://doi.org/10.1093/burnst/tkaa006
Xiangwen Xu, Shuchen Gu, Xin Huang, 等. The role of macrophages in the formation of hypertrophic scars and keloids[J]. Burns & Trauma, 2020,8(1). DOI： 10.1093/burnst/tkaa006.

Xiangwen Xu, Shuchen Gu, Xin Huang, Jieyi Ren, Yihui Gu, Chengjiang Wei, Xiang Lian, Haizhou Li, Yashan Gao, Rui Jin, Bin Gu, Tao Zan, Zhichao Wang, The role of macrophages in the formation of hypertrophic scars and keloids, Burns & Trauma, Volume 8, 2020, tkaa006, https://doi.org/10.1093/burnst/tkaa006 DOI：

摘要

Abstract

Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation. However

few reviews have highlighted the significance of macrophages during the formation of abnormal scars. The purpose of this review was to outline the polarization of macrophages from early to late stage of pathological scar formation

focusing on spatiotemporal diversity of M1 and M2 macrophages. In this review

the role of macrophages in the formation of hypertrophic scars and keloids is summarized in detail. First

an increased number of M2 cells observed before injuries are significantly associated with susceptibility to abnormal scar pathogenesis. Second

decreased expression of M1 at the early stage and delayed expression of M2 at the late stage results in pathological scar formation. Third

M2 cells are highly expressed at both the margin and the superficial region

which is consistent with the invasive property of keloids. Finally

this review helps to characterize strategies for the prediction and prevention of pathological scar formation.

关键词

Keywords

Hypertrophic scarKeloidMacrophagesPredispositionWound healing

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