Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics

Daniel G Metcalf; Philip G Bowler

doi:10.1093/burnst/tkaa004

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Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics

更新时间：2022-06-09

- Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics
- Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics
- Burns & Trauma 2020年8卷第1期
- 作者机构：
  
  Science & Technology
- 作者简介：
- 基金信息：
  
  The original real-world evaluation was funded by ConvaTec Ltd.
- DOI：10.1093/burnst/tkaa004
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-3-4，
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Daniel G Metcalf, Philip G Bowler. Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics[J]. Burns & Trauma, 2020,8(1).

Daniel G Metcalf, Philip G Bowler, Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics, Burns & Trauma, Volume 8, 2020, tkaa004, https://doi.org/10.1093/burnst/tkaa004
Daniel G Metcalf, Philip G Bowler. Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics[J]. Burns & Trauma, 2020,8(1). DOI： 10.1093/burnst/tkaa004.

Daniel G Metcalf, Philip G Bowler, Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics, Burns & Trauma, Volume 8, 2020, tkaa004, https://doi.org/10.1093/burnst/tkaa004 DOI：

摘要

Abstract

BackgroundHard-to-heal wounds are often compromised by the presence of biofilm. This presents an infection risk

yet traditional antimicrobial wound care products and systemic antibiotics are often used despite the uncertainty of therapeutic success and wound progression. The aim of this study was to investigate the clinical impact of a next-generation anti-biofilm Hydrofiber wound dressing (AQUACEL Ag+ Extra[AQAg+ E]) in hard-to-heal wounds that had previously been treated unsuccessfully with traditional silver-

iodine- or polyhexamethylene biguanide (PHMB)-containing dressings and products and/or systemic antibiotics.MethodsClinical case study evaluations of the anti-biofilm dressing were conducted

where deteriorating or stagnant wounds were selected by clinicians and primary dressings were replaced by the anti-biofilm dressing for up to 4 weeks

or as deemed clinically appropriate

with monitoring via case report forms. The data was stratified for cases where traditional silver-

iodine- or PHMB-containing products

or systemic antibiotics

had been used prior to the introduction of the anti-biofilm dressing.ResultsSixty-five cases were identified for inclusion

wounds ranging in duration from 1 week to 20 years (median: 12 months). In 47 (72%) cases the wounds were stagnant

while 15 (23%) were deteriorating; 3 wounds were not recorded. After an average of 4.2 weeks of management with the anti-biofilm dressing (range: 1–11 weeks)

in 11 (17%) cases the wounds had healed (i.e. complete wound closure)

40 (62%) wounds improved

9 (14%) wounds remained the same and 5 (8%) wounds deteriorated.ConclusionsThe introduction of this anti-biofilm dressing into protocols of care that had previously involved wound management with traditional antimicrobial products and/or antibiotics was shown to facilitate improvements in the healing status of most of these hard-to-heal wounds. Dressings containing proven anti-biofilm technology

in combination with antimicrobial silver and exudate management technology

appear to be an effective alternative to traditional antimicrobial products and antibiotics in the cases presented here. The use of antimicrobial wound dressings that contain anti-biofilm technology may have a key role to play in more effective wound management and antibiotic stewardship.

关键词

Keywords

AntibioticsAntimicrobialsAQUACEL Ag+ ExtraBiofilmDressingsIodineHard-to-heal woundsPolyhexamethylene biguanideSilver

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