Application of stem cells in peripheral nerve regeneration

Sheng Yi; Yu Zhang; Xiaokun Gu; Li Huang; Kairong Zhang; Tianmei Qian; Xiaosong Gu

doi:10.1093/burnst/tkaa002

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Application of stem cells in peripheral nerve regeneration

更新时间：2022-06-09

- Application of stem cells in peripheral nerve regeneration
- Application of stem cells in peripheral nerve regeneration
- Burns & Trauma 2020年8卷第1期
- 作者机构：
  
  1. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education
  2. Nuclear Medicine Department
- 作者简介：
- 基金信息：
  
  This work was supported by the National Major Project of Research and Development [grant numbers 2017YFA0104700 and 2016YFC1101603], the National Natural Science Foundation of China [grant numbers 31730031 and 31700926], Jiangsu Provincial Key Medical Center and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China [PAPD].
- DOI：10.1093/burnst/tkaa002
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-2-27，
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Sheng Yi, Yu Zhang, Xiaokun Gu, 等. Application of stem cells in peripheral nerve regeneration[J]. Burns & Trauma, 2020,8(1).

Sheng Yi, Yu Zhang, Xiaokun Gu, Li Huang, Kairong Zhang, Tianmei Qian, Xiaosong Gu, Application of stem cells in peripheral nerve regeneration, Burns & Trauma, Volume 8, 2020, tkaa002, https://doi.org/10.1093/burnst/tkaa002
Sheng Yi, Yu Zhang, Xiaokun Gu, 等. Application of stem cells in peripheral nerve regeneration[J]. Burns & Trauma, 2020,8(1). DOI： 10.1093/burnst/tkaa002.

Sheng Yi, Yu Zhang, Xiaokun Gu, Li Huang, Kairong Zhang, Tianmei Qian, Xiaosong Gu, Application of stem cells in peripheral nerve regeneration, Burns & Trauma, Volume 8, 2020, tkaa002, https://doi.org/10.1093/burnst/tkaa002 DOI：

摘要

Abstract

Traumatic peripheral nerve injury is a worldwide clinical issue with high morbidity. The severity of peripheral nerve injury can be classified as neurapraxia

axonotmesis or neurotmesis

according to Seddon’s classification

or five different degrees according to Sunderland’s classification. Patients with neurotmesis suffer from a complete transection of peripheral nerve stumps and are often in need of surgical repair of nerve defects. The applications of autologous nerve grafts as the golden standard for peripheral nerve transplantation meet some difficulties

including donor nerve sacrifice and nerve mismatch. Attempts have been made to construct tissue-engineered nerve grafts as supplements or even substitutes for autologous nerve grafts to bridge peripheral nerve defects. The incorporation of stem cells as seed cells into the biomaterial-based scaffolds increases the effectiveness of tissue-engineered nerve grafts and largely boosts the regenerative process. Numerous stem cells

including embryonic stem cells

neural stem cells

bone marrow mesenchymal stem cells

adipose stem cells

skin-derived precursor stem cells and induced pluripotent stem cells

have been used in neural tissue engineering. In the current review

recent trials of stem cell-based tissue-engineered nerve grafts have been summarized; potential concerns and perspectives of stem cell therapeutics have also been contemplated.

关键词

Keywords

Peripheral nerve injuryTissue-engineered nerve graftsSeed cellsStem cellsPeripheral nerve regeneration

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