Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

David Sánchez-Marín; Macrina Beatriz Silva-Cázares; Fany Iris Porras-Reyes; Rebeca García-Román; Alma D. Campos-Parra

doi:10.1016/j.gendis.2023.101136

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Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

Review article | 更新时间：2024-02-04

- Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer
- Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer
- Genes & Diseases 2024年11卷第3期
- 作者机构：
  
  1. Posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04360, México
  2. Instituto de Salud Pública, Universidad Veracruzana (UV), Av. Dr Luis, Dr. Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa, Veracruz, C.P. 91190, México
  3. Servicio de Anatomía Patológica, Instituto Nacional de Cancerología (INCan), Niño Jesús, Tlalpan, Ciudad de México, C.P. 14080, México
  4. Unidad Académica Multidisciplinaria Región Altiplano, Universidad Autónoma de San Luis Potosí (UASLP), Carretera a Cedral Km 5+600, Ejido San José de la Trojes, Matehuala, San Luis Potosí, C.P. 78760, México
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.101136
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-5-1，
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David Sánchez-Marín, Macrina Beatriz Silva-Cázares, Fany Iris Porras-Reyes, 等. Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer[J]. Genes & Diseases, 2024,11(3).

David Sánchez-Marín, Macrina Beatriz Silva-Cázares, Fany Iris Porras-Reyes, et al. Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer[J]. Genes & Diseases, 2024,11(3).
David Sánchez-Marín, Macrina Beatriz Silva-Cázares, Fany Iris Porras-Reyes, 等. Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer[J]. Genes & Diseases, 2024,11(3). DOI： 10.1016/j.gendis.2023.101136.

David Sánchez-Marín, Macrina Beatriz Silva-Cázares, Fany Iris Porras-Reyes, et al. Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer[J]. Genes & Diseases, 2024,11(3). DOI： 10.1016/j.gendis.2023.101136.

摘要

Abstract

Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides with dynamic regulatory functions. They interact with a wide range of molecules such as DNA

RNA

and proteins to modulate diverse cellular functions through several mechanisms and

if deregulated

they can lead to cancer development and progression. Recently

it has been described that lncRNAs are susceptible to form gene fusions with mRNAs or other lncRNAs

breaking the paradigm of gene fusions consisting mainly of protein-coding genes. However

their biological significance in the tumor phenotype is still uncertain. Therefore

their recent identification opens a new line of research to study their biological role in tumorigenesis

and their potential as biomarkers with clinical relevance or as therapeutic targets. The present study aimed to review the lncRNA fusions identified so far and to know which of them have been associated with a potential function. We address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window in cancer.

关键词

Keywords

CancerGene fusionslncRNAsncRNAsTherapy

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