Oncogenic MORC2 in cancer development and beyond

Shan Zhang; Ayao Guo; Huan Wang; Jia Liu; Chenshuang Dong; Junyi Ren; Guiling Wang

doi:10.1016/j.gendis.2023.05.010

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Oncogenic MORC2 in cancer development and beyond

Review article | 更新时间：2024-02-04

- Oncogenic MORC2 in cancer development and beyond
- Oncogenic MORC2 in cancer development and beyond
- Genes & Diseases 2024年11卷第2期
- 作者机构：
  
  1. Key Laboratory of Cell Biology, Department of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University,Liaoning,Shenyang,China,110122
  2. Department of Breast Surgery, The First Affiliated Hospital of China Medical University,Liaoning,Shenyang,China,110001
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.05.010
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-3-1，
扫描看全文
Shan Zhang, Ayao Guo, Huan Wang, 等. Oncogenic MORC2 in cancer development and beyond[J]. Genes & Diseases, 2024,11(2).

Shan Zhang, Ayao Guo, Huan Wang, et al. Oncogenic MORC2 in cancer development and beyond[J]. Genes & Diseases, 2024,11(2).
Shan Zhang, Ayao Guo, Huan Wang, 等. Oncogenic MORC2 in cancer development and beyond[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.05.010.

Shan Zhang, Ayao Guo, Huan Wang, et al. Oncogenic MORC2 in cancer development and beyond[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.05.010.

摘要

Abstract

Microrchidia CW-type zinc finger 2 (MORC2) is a member of the MORC superfamily of nuclear proteins. Growing evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor suppressors. The present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target genes. This systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future.

关键词

Keywords

Cancer developmentHallmarks of cancerMORC2Therapeutic targetTreatment resistance

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