Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways

Xiaoxuan Wang; Lijuan Luo; Jingtao Xu; Qiuping Lu; Haichao Xia; Yanran Huang; Lulu Zhang; Liping Xie; Habu Jiwa; Shiqiong Liang; Xiaoji Luo; Jinyong Luo

doi:10.1016/j.gendis.2023.03.031

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Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways

Full-length article | 更新时间：2024-02-04

- Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways
- Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways
- Genes & Diseases 2024年11卷第2期
- 作者机构：
  
  1. Key Laboratory of Diagnostic Medicine Designated By the Chinese Ministry of Education, School of Laboratory Medicine, Chongqing Medical University,Chongqing,China,400016
  2. Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400042
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.031
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-3-1，
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Xiaoxuan Wang, Lijuan Luo, Jingtao Xu, 等. Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways[J]. Genes & Diseases, 2024,11(2).

Xiaoxuan Wang, Lijuan Luo, Jingtao Xu, et al. Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways[J]. Genes & Diseases, 2024,11(2).
Xiaoxuan Wang, Lijuan Luo, Jingtao Xu, 等. Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.03.031.

Xiaoxuan Wang, Lijuan Luo, Jingtao Xu, et al. Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.03.031.

摘要

Abstract

Bladder cancer (BC) is one of the most common malignant tumors in the urinary system. Due to the poor prognosis and high mortality rate of the disease

it is urgent to develop new drugs with high efficacy and low toxicity to treat BC. Echinatin (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor potential. Herein

we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular mechanism. We found that Ecn

in vitro

inhibited the proliferation

migration

and invasion

arrested the cell cycle at the G2/M phase

and promoted apoptosis in BC cells. Besides

Ecn had no notable cytotoxicity towards human normal cells. We subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells

in vivo

. Mechanistically

Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway

while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC cells. Remarkably

Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC cells. In summary

our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and Wnt/β-catenin signaling pathways. More meaningfully

our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn.

关键词

Keywords

Bladder cancerCombination chemotherapyEchinatinp38Wnt/β-catenin

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