The journey towards physiology and pathology: Tracing the path of neuregulin 4

Min Chen; Jieying Zhu; Hongyang Luo; Wangjing Mu; Liang Guo

doi:10.1016/j.gendis.2023.03.021

您当前的位置：

首页 >

文章列表页 >

The journey towards physiology and pathology: Tracing the path of neuregulin 4

Review article | 更新时间：2024-02-04

- The journey towards physiology and pathology: Tracing the path of neuregulin 4
- The journey towards physiology and pathology: Tracing the path of neuregulin 4
- Genes & Diseases 2024年11卷第2期
- 作者机构：
  
  School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport,Shanghai,China,200438
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.021
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-3-1，
扫描看全文
The journey towards physiology and pathology: Tracing the path of neuregulin 4[J]. Genes & Diseases, 2024,11(2).

Min Chen, Jieying Zhu, Hongyang Luo, et al. The journey towards physiology and pathology: Tracing the path of neuregulin 4[J]. Genes & Diseases, 2024,11(2).
The journey towards physiology and pathology: Tracing the path of neuregulin 4[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.03.021.

Min Chen, Jieying Zhu, Hongyang Luo, et al. The journey towards physiology and pathology: Tracing the path of neuregulin 4[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.03.021.

摘要

Abstract

Neuregulin 4 (Nrg4)

an epidermal growth factor (EGF) family member

can bind to and activate the ErbB4 receptor tyrosine kinase. Nrg4 has five different isoforms by alternative splicing and performs a wide variety of functions. Nrg4 is involved in a spectrum of physiological processes including neurobiogenesis

lipid metabolism

glucose metabolism

thermogenesis

and angiogenesis. In pathological processes

Nrg4 inhibits inflammatory factor levels and suppresses apoptosis in inflammatory diseases. In addition

Nrg4 could ameliorate obesity

insulin resistance

and cardiovascular diseases. Furthermore

Nrg4 improves non-alcoholic fatty liver disease (NAFLD) by promoting autophagy

improving lipid metabolism

and inhibiting cell death of hepatocytes. Besides

Nrg4 is closely related to the development of cancer

hyperthyroidism

and some other diseases. Therefore

elucidation of the functional role and mechanisms of Nrg4 will provide a clearer view of the therapeutic potential and possible risks of Nrg4.

关键词

Keywords

AngiogenesisCardiovascular diseasesInflammationInsulin resistanceLipid and glucose metabolismNAFLDNeurobiogenesisObesity

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

Adipose-derived stem cells and obesity: The spear and shield relationship

Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration

Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges

Transcriptional control by HNF-1: Emerging evidence showing its role in lipid metabolism and lipid metabolism disorders

HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies