N6-methyladenosine (m

6

A) is a dynamic and reversible epigenetic regulation. As the most prevalent internal post-transcriptional modification in eukaryotic RNA

it participates in the regulation of gene expression through various mechanisms

such as mRNA splicing

nuclear export

localization

translation efficiency

mRNA stability

and structural transformation. The involvement of m6A in the regulation of gene expression depends on the specific recognition of m6A-modified RNA by reader proteins. In the pathogenesis and treatment of liver disease

studies have found that the expression levels of key genes that promote or inhibit the development of liver disease are regulated by m

6

A modification

in which abnormal expression of reader proteins determines the fate of these gene transcripts. In this review

we introduce m

6

A readers

summarize the recognition and regulatory mechanisms of m

6

A readers on mRNA

and focus on the biological functions and mechanisms of m

6

A readers in liver cancer

viral hepatitis

non-alcoholic fatty liver disease (NAFLD)

hepatic fibrosis (HF)

acute liver injury (ALI)

and other liver diseases. This information is expected to be of high value to researchers deciphering the links between m

6

A readers and human liver diseases.