DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects

Xinhui Wang; Yaqi Dong; Hong Zhang; Yinghui Zhao; Tianshu Miao; Ghazal Mohseni; Lutao Du

doi:10.1016/j.gendis.2023.02.038

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DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects

Review article | 更新时间：2024-02-04

- DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects
- DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects
- Genes & Diseases 2024年11卷第2期
- 作者机构：
  
  1. Department of Biochemistry and Molecular Biology, Shandong University School of Basic Medical Sciences,Shandong,Jinan,China,250012
  2. Department of Clinical Laboratory, The Second Hospital of Shandong University,Shandong,Jinan,China,250033
  3. Shandong Engineering & Technology Research Center for Tumor Marker Detection,Shandong,Jinan,China,250033
  4. Suzhou Research Institute of Shandong University,Jiangsu,Suzhou,China,215123
  5. Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory,Shandong,Jinan,China,250033
  6. Department of Clinical Laboratory, Fuling Hospital, Chongqing University,Chongqing,China,402774
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.038
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-3-1，
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Xinhui Wang, Yaqi Dong, Hong Zhang, 等. DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects[J]. Genes & Diseases, 2024,11(2).

Xinhui Wang, Yaqi Dong, Hong Zhang, et al. DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects[J]. Genes & Diseases, 2024,11(2).
Xinhui Wang, Yaqi Dong, Hong Zhang, 等. DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.02.038.

Xinhui Wang, Yaqi Dong, Hong Zhang, et al. DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.02.038.

摘要

Abstract

Gastric cancer (GC) is one of the most common and deadly cancers worldwide. Early detection offers the best chance for curative treatment and reducing its mortality. However

the optimal population-based early screening for GC remains unmet. Aberrant DNA methylation occurs in the early stage of GC

exhibiting cancer-specific genetic and epigenetic changes

and can be detected in the media such as blood

gastric juice

and feces

constituting a valuable biomarker for cancer early detection. Furthermore

DNA methylation is a stable epigenetic alteration

and many innovative methods have been developed to quantify it rapidly and accurately. Nonetheless

large-scale clinical validation of DNA methylation serving as tumor biomarkers is still lacking

precluding their implementation in clinical practice. In conclusion

after a critical analysis of the recent existing literature

we summarized the evolving roles of DNA methylation during GC occurrence

expounded the newly discovered noninvasive DNA methylation biomarkers for early detection of GC

and discussed its challenges and prospects in clinical applications.

关键词

Keywords

BiomarkersDNA methylationEarly detectionGastric cancerTranslation

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