Long noncoding RNA (lncRNA) <em>H19</em>: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases

Junyi Liao; Bowen Chen; Zhenglin Zhu; Chengcheng Du; Shengqiang Gao; Guozhi Zhao; Piao Zhao; Yonghui Wang; Annie Wang; Zander Schwartz; Lily Song; Jeffrey Hong; William Wagstaff; Rex C. Haydon; Hue H. Luu; Jiaming Fan; Russell R. Reid; Tong-Chuan He; Lewis Shi; Ning Hu; Wei Huang

doi:10.1016/j.gendis.2023.02.008

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Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases

Review article | 更新时间：2023-08-29

- Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases
- Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases
- Genes & Diseases 2023年10卷第4期
- 作者机构：
  
  1. School of Biomedical Engineering, Vanderbilt University,TN,Nashville,USA,37235
  2. Ministry of Education Key Laboratory of Diagnostic Medicine, Department of Clinical Biochemistry, The School of Laboratory Medicine, Chongqing Medical University,Chongqing,China,400016
  3. Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637
  4. Departments of Orthopedic Surgery and Urology, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
  5. Department of Clinical Laboratory Medicine, Shanghai Jiaotong University School of Medicine,Shanghai,China,200000
  6. The Medical Scientist Training Program, The University of Chicago Pritzker School of Medicine,IL,Chicago,USA,60637
  7. Orthopedic Research Center, Chongqing Medical University,Chongqing,China,400016
  8. Laboratory of Craniofacial Suture Biology and Development, Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center,IL,Chicago,USA,60637
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.008
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-7-1，
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Junyi Liao, Bowen Chen, Zhenglin Zhu, 等. Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases[J]. Genes & Diseases, 2023,10(4).

Junyi Liao, Bowen Chen, Zhenglin Zhu, et al. Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases[J]. Genes & Diseases, 2023,10(4).
Junyi Liao, Bowen Chen, Zhenglin Zhu, 等. Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases[J]. Genes & Diseases, 2023,10(4). DOI： 10.1016/j.gendis.2023.02.008.

Junyi Liao, Bowen Chen, Zhenglin Zhu, et al. Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases[J]. Genes & Diseases, 2023,10(4). DOI： 10.1016/j.gendis.2023.02.008.

摘要

Abstract

Recent advances in deep sequencing technologies have revealed that

while less than 2% of the human genome is transcribed into mRNA for protein synthesis

over 80% of the genome is transcribed

leading to the production of large amounts of noncoding RNAs (ncRNAs). It has been shown that ncRNAs

especially long non-coding RNAs (lncRNAs)

may play crucial regulatory roles in gene expression. As one of the first isolated and reported lncRNAs

9 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis

development

tumorigenesis

osteogenesis

and metabolism. Mechanistically

H19

mediates diverse regulatory functions by serving as competing endogenous RNAs (CeRNAs)

Igf2/H19

imprinted tandem gene

modular scaffold

cooperating with

H19

antisense

and acting directly with other mRNAs or lncRNAs. Here

we summarized the current understanding of

H19

in embryogenesis and development

cancer development and progression

mesenchymal stem cell lineage-specific differentiation

and metabolic diseases. We discussed the potential regulatory mechanisms underlying

H19

's functions in those processes although more in-depth studies are warranted to delineate the exact molecular

cellular

epigenetic

and genomic regulatory mechanisms underlying the physiological and pathological roles of

H19

. Ultimately

these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting

H19

functions.

关键词

Keywords

CancerEpigenetic regulationH19LncRNALong-noncoding RNAMetabolic diseasesStem cell differentiation

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Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases

Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases

DOI：10.1016/j.gendis.2023.02.008

摘要

Abstract

关键词

Keywords

references