Fantastic voyage: The journey of NLRP3 inflammasome activation

Xiangyong Que; Sihao Zheng; Qibin Song; Huadong Pei; Pingfeng Zhang

doi:10.1016/j.gendis.2023.01.009

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Fantastic voyage: The journey of NLRP3 inflammasome activation

Review article | 更新时间：2024-02-04

- Fantastic voyage: The journey of NLRP3 inflammasome activation
- Fantastic voyage: The journey of NLRP3 inflammasome activation
- Genes & Diseases 2024年11卷第2期
- 作者机构：
  
  1. Cancer Center, Renmin Hospital of Wuhan University,Hubei,Wuhan,China,430060
  2. Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,, DC,Washington,USA,20057
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.01.009
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-3-1，
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Xiangyong Que, Sihao Zheng, Qibin Song, 等. Fantastic voyage: The journey of NLRP3 inflammasome activation[J]. Genes & Diseases, 2024,11(2).

Xiangyong Que, Sihao Zheng, Qibin Song, et al. Fantastic voyage: The journey of NLRP3 inflammasome activation[J]. Genes & Diseases, 2024,11(2).
Xiangyong Que, Sihao Zheng, Qibin Song, 等. Fantastic voyage: The journey of NLRP3 inflammasome activation[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.01.009.

Xiangyong Que, Sihao Zheng, Qibin Song, et al. Fantastic voyage: The journey of NLRP3 inflammasome activation[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.01.009.

摘要

Abstract

NLRP3 inflammasome

an intracellular multiprotein complex

can be activated by a range of pathogenic microbes or endogenous hazardous chemicals. Its activation results in the release of cytokines such as IL-1β and IL-18

as well as Gasdermin

which eventually causes pyroptosis. The activation of NLRP3 inflammasome is under strict control and regulation by numerous pathways and mechanisms. Its excessive activation can lead to a persistent inflammatory response

which is linked to the onset and progression of severe illnesses. Recent studies have revealed that the subcellular localization of NLRP3 changes significantly during the activation process. In this review

we review the current understanding of the molecular mechanism of NLRP3 inflammasome activation

focusing on the subcellular localization of NLRP3 and the associated regulatory mechanisms. We aim to provide a comprehensive understanding of the dynamic transportation

activation

and degradation processes of NLRP3.

关键词

Keywords

Inflammasome activationInnate immunityNLRP3NLRP3 inflammasomeSubcellular localization

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