Signaling pathways governing the behaviors of leukemia stem cells

Shirin Azizidoost; Ava Nasrolahi; Mohadeseh Sheykhi-Sabzehpoush; Amir Anbiyaiee; Seyed Esmaeil Khoshnam; Maryam Farzaneh; Shahab Uddin

doi:10.1016/j.gendis.2023.01.008

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Signaling pathways governing the behaviors of leukemia stem cells

Review article | 更新时间：2024-02-04

- Signaling pathways governing the behaviors of leukemia stem cells
- Signaling pathways governing the behaviors of leukemia stem cells
- Genes & Diseases 2024年11卷第2期
- 作者机构：
  
  1. Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
  2. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
  3. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
  4. Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran 219367,Iran,2411
  5. Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha,Qatar,3050
  6. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
  7. Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.01.008
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-3-1，
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Shirin Azizidoost, Ava Nasrolahi, Mohadeseh Sheykhi-Sabzehpoush, 等. Signaling pathways governing the behaviors of leukemia stem cells[J]. Genes & Diseases, 2024,11(2).

Shirin Azizidoost, Ava Nasrolahi, Mohadeseh Sheykhi-Sabzehpoush, et al. Signaling pathways governing the behaviors of leukemia stem cells[J]. Genes & Diseases, 2024,11(2).
Shirin Azizidoost, Ava Nasrolahi, Mohadeseh Sheykhi-Sabzehpoush, 等. Signaling pathways governing the behaviors of leukemia stem cells[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.01.008.

Shirin Azizidoost, Ava Nasrolahi, Mohadeseh Sheykhi-Sabzehpoush, et al. Signaling pathways governing the behaviors of leukemia stem cells[J]. Genes & Diseases, 2024,11(2). DOI： 10.1016/j.gendis.2023.01.008.

摘要

Abstract

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia

understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways

including Notch

Wnt

Hedgehog

and STAT3. LSCs are highly proliferative cells that stimulate tumor initiation

migration

EMT

and drug resistance. This review summarizes cellular pathways that stimulate and prevent LSCs' self-renewal

metastasis

and tumorigenesis.

关键词

Keywords

LeukemiaLeukemia stem cellsPathogenesisSignaling pathwaysStem cells

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