Metabolic cardiovascular diseases have become a global health concern

and some of their risk factors are linked to several metabolic disorders. They are the leading causes of death in developing countries. Adipose tissues secrete a variety of adipokines that participate in regulating metabolism and various pathophysiological processes. Adiponectin is the most abundant pleiotropic adipokine and can increase insulin sensitivity

improve atherosclerosis

have anti-inflammatory properties

and exert a cardioprotective effect. Low adiponectin concentrations are correlated with myocardial infarction

coronary atherosclerotic heart disease

hypertrophy

hypertension

and other metabolic cardiovascular dysfunctions. However

the relationship between adiponectin and cardiovascular diseases is complex

and the specific mechanism of action is not fully understood. Our summary and analysis of these issues are expected to contribute to future treatment options.