Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases

Hongliang Liu; Wenjing Hao; Jiao Yang; Yuliang Zhang; Xinfang Wang; Chunming Zhang

doi:10.1016/j.gendis.2022.10.015

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Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases

Review article | 更新时间：2023-08-29

- Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases
- Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases
- Genes & Diseases 2023年10卷第5期
- 作者机构：
  
  1. Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  2. Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  3. Department of Cell Biology and Genetics, The Basic Medical School of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  4. Department of Anatomy, The Basic Medical School of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  5. Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University,Shanxi,Taiyuan,China,030001
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.015
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-9-1，
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Hongliang Liu, Wenjing Hao, Jiao Yang, 等. Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases[J]. Genes & Diseases, 2023,10(5).

Hongliang Liu, Wenjing Hao, Jiao Yang, et al. Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases[J]. Genes & Diseases, 2023,10(5).
Hongliang Liu, Wenjing Hao, Jiao Yang, 等. Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.10.015.

Hongliang Liu, Wenjing Hao, Jiao Yang, et al. Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.10.015.

摘要

Abstract

Circular RNAs (circRNAs) are a special class of single-stranded RNA molecules with covalently closed loops widely expressed in eukaryotic organisms. CircRNAs have long been considered to play important roles in various physiological and pathological processes as non-coding RNAs. However

circRNAs have recently garnered considerable attention due to their ability to be translated into peptides/proteins via internal ribosome entry site- or N6-methyladenosine-mediated pathways or rolling translation mechanisms. Furthermore

dysregulation of translatable circRNAs and their encoded proteins has been associated with developing and progressing diseases such as cancer. This review aims to summarize the driving mechanisms of circRNA translation and the available strategies in circRNA translation research. The main focus is on the emerging biological functions of translatable circRNAs

their regulatory mechanisms

and potential clinical applications in human diseases to provide new perspectives on disease diagnosis

prognosis

and targeted therapy.

关键词

Keywords

Circular RNAClinical applicationsFunctionPeptideTranslation

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