Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma

Meiyu Qu; Qiangqiang He; Jiahao Luo; Tingyu Shen; Ruibo Gao; Yana Xu; Chengyun Xu; Muhammad Qasim Barkat; Ling-Hui Zeng; Ximei Wu

doi:10.1016/j.gendis.2022.10.014

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Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma

Review article | 更新时间：2023-08-29

- Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma
- Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma
- Genes & Diseases 2023年10卷第5期
- 作者机构：
  
  1. Department of Pharmacology, Zhejiang University City College,Zhejiang,Hangzhou,China,310015
  2. Department of Pharmacology, Zhejiang University School of Medicine,Zhejiang,Hangzhou,China,310058
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.014
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-9-1，
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Meiyu Qu, Qiangqiang He, Jiahao Luo, 等. Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma[J]. Genes & Diseases, 2023,10(5).

Meiyu Qu, Qiangqiang He, Jiahao Luo, et al. Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma[J]. Genes & Diseases, 2023,10(5).
Meiyu Qu, Qiangqiang He, Jiahao Luo, 等. Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.10.014.

Meiyu Qu, Qiangqiang He, Jiahao Luo, et al. Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.10.014.

摘要

Abstract

lternative splicing (AS) produces the different mRNA splicing bodies

which are then translated into multiple protein isoforms and participate in various biological functions. With a deeper understanding of alternative splicing through the study of transcriptomes using high-throughput sequencing-based methods

the correlation between aberrant AS and diseases triggered a great concern

especially abnormal AS and cancer. Medulloblastoma (MB) is an intracranial tumor in children. Sonic hedgehog MB (SHH-MB) accounted for approximately 30% of MB

which is associated with the activation of SHH signaling. Growing evidence shows that aberrant AS is closely related to the tumorigenesis of MB. Here

we briefly introduced the AS and its mechanism. Next

we described canonical/noncanonical hedgehog signaling and its correlation with MB. The main description focused on AS of various regulators in canonical hedgehog signaling in MB. In addition

we also described AS of various regulators in noncanonical hedgehog signaling. Meanwhile

activated hedgehog signaling also induces AS in MB. Then

we pointed out that aberrant AS of hedgehog signaling is associated with different MB subgroups. Finally

we summarized the therapeutic applications of targeted AS in cancer treatment. In summary

further understanding of AS in SHH-MB could develop therapeutic targets for splicing factors which may be a novel therapeutic strategy.

关键词

Keywords

Alternative splicingExonHedgehog signalingMedulloblastomaTumor suppressor

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