1. Departments of Orthopaedic Surgery and Urology, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016

2. School of Biomedical Engineering, Vanderbilt University,TN,Nashville,USA,37235

3. Department of Clinical Laboratory Medicine, Shanghai Jiaotong University School of Medicine,Shanghai,China,200000

4. Laboratory of Craniofacial Suture Biology and Development, Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center,IL,Chicago,USA,60637

5. Molecular Oncology Laboratory, Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637