The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

Junyang Huang; Kun Zhang; Ruolin Du; Wanling Liu; Haijun Zhang; Tian Tian; Yazhou Wang; Tieying Yin

doi:10.1016/j.gendis.2022.08.015

您当前的位置：

首页 >

文章列表页 >

The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

Review article | 更新时间：2023-08-29

- The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation
- The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation
- Genes & Diseases 2023年10卷第5期
- 作者机构：
  
  1. School of Medicine, Chongqing University,Chongqing,China,400030
  2. Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University,Chongqing,China,400030
  3. Department of Vascular & Intervention, Tenth Peoples' Hospital of Tongji University,Shanghai,China,200072
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.08.015
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-9-1，
扫描看全文
Junyang Huang, Kun Zhang, Ruolin Du, 等. The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation[J]. Genes & Diseases, 2023,10(5).

Junyang Huang, Kun Zhang, Ruolin Du, et al. The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation[J]. Genes & Diseases, 2023,10(5).
Junyang Huang, Kun Zhang, Ruolin Du, 等. The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.08.015.

Junyang Huang, Kun Zhang, Ruolin Du, et al. The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.08.015.

摘要

Abstract

In recent years

cardiovascular health problems are becoming more and more serious. At the same time

mechanical stimulation closely relates to cardiovascular health. In this context

Piezo1

which is very sensitive to mechanical stimulation

has attracted our attention. Here

we review the critical significance of Piezo1 in mechanical stimulation of endothelial cells

NO production

lipid metabolism

DNA damage protection

the development of new blood vessels and maturation

narrowing of blood vessels

blood pressure regulation

vascular permeability

insulin sensitivity

and maintenance of red blood cell function. Besides

Piezo1 may participate in the occurrence and development of atherosclerosis

diabetes

hypertension

and other cardiovascular diseases. It is worth noting that Piezo1 has dual effects on maintaining cardiovascular health. On the one hand

the function of Piezo1 is necessary to maintain cardiovascular health; on the other hand

under some extreme mechanical stimulation

the overexpression of Piezo1 may bring adverse factors such as inflammation. Therefore

this review discusses the Janus-faced role of Piezo1 in maintaining cardiovascular health and puts forward new ideas to provide references for gene therapy or nanoagents targeting Piezo1.

关键词

Keywords

AtherosclerosisCardiovascular diseaseEndothelial cells (ECs)Mechanical stimulationPiezo1

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction

Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis

New insights into the suppression of inflammation and lipid accumulation by JAZF1

Cathepsin K contributed to disturbed flow-induced atherosclerosis is dependent on integrin-actin cytoskeleton–NF–κB pathway

Sterol carrier protein 2: A promising target in the pathogenesis of atherosclerosis