Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis

Yuan Yuan; Guoqiang Qiao; Jiajiao Zhou; Yilu Zhou; Yali Li; Xia Li; Zhenglin Jiang; Yihua Wang

doi:10.1016/j.gendis.2022.08.012

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Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis

Full-length article | 更新时间：2023-08-29

- Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis
- Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis
- Genes & Diseases 2023年10卷第3期
- 作者机构：
  
  1. Institute for Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom
  2. Department of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University,Jiangsu,Nantong,China,226019
  3. Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.08.012
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-5-1，
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Yuan Yuan, Guoqiang Qiao, Jiajiao Zhou, 等. Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis[J]. Genes & Diseases, 2023,10(3).

Yuan Yuan, Guoqiang Qiao, Jiajiao Zhou, et al. Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis[J]. Genes & Diseases, 2023,10(3).
Yuan Yuan, Guoqiang Qiao, Jiajiao Zhou, 等. Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis[J]. Genes & Diseases, 2023,10(3). DOI： 10.1016/j.gendis.2022.08.012.

Yuan Yuan, Guoqiang Qiao, Jiajiao Zhou, et al. Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis[J]. Genes & Diseases, 2023,10(3). DOI： 10.1016/j.gendis.2022.08.012.

摘要

Abstract

Idiopathic pulmonary fibrosis (IPF) is a dreadful

chronic

and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here

we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients

several potential mechanisms of relevance to IPF pathology were identified

including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together

these data support HBO treatment as a viable strategy against pulmonary fibrosis.

关键词

Keywords

Epithelial-mesenchymal transitionHyperbaricoxygenHypoxiaPulmonary fibrosisSystematic analysis

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