Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway

Yi Shen; Jun Li; Dan Peng; Lele Liao; Xia Chen; Weiye Zhong; Zicheng Liu; Chao Yu; Yuanliang Sun

doi:10.1016/j.gendis.2022.06.010

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Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway

Full-length article | 更新时间：2023-08-29

- Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway
- Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway
- Genes & Diseases 2023年10卷第5期
- 作者机构：
  
  1. Department of Orthopaedics, The Second Xiangya Hospital of Central South University,Hunan,Changsha,China,410000
  2. Department of Spine Surgery, Affiliated Hospital of Qingdao University,Shandong,Qingdao,China,266000
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.06.010
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-9-1，
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Yi Shen, Jun Li, Dan Peng, 等. Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway[J]. Genes & Diseases, 2023,10(5).

Yi Shen, Jun Li, Dan Peng, et al. Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway[J]. Genes & Diseases, 2023,10(5).
Yi Shen, Jun Li, Dan Peng, 等. Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.06.010.

Yi Shen, Jun Li, Dan Peng, et al. Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.06.010.

摘要

Abstract

Osteosarcoma is a common malignant tumor occurring in children and young adults. Chondroitin sulfate (CS) participates in cell adhesion

cell division

and the formation of neural networks in the body

the biosynthesis of which requires the participation of glycosyltransferases. CHPF

a glycosyltransferase

plays a role in the extension of CS. Recently

CHPF's biological roles and functional importance in human diseases including malignant tumors have been widely discussed. However

whether CHPF is involved in osteosarcoma development and growth has not been revealed. The present work aimed to investigate the expression levels

functional significance and molecular mechanism of CHPF in osteosarcoma progression. Our results revealed that CHPF is strongly expressed in osteosarcoma tissues and cells. Furthermore

CHPF serves as a tumor promoter in the development and progression of osteosarcoma through enhancing cell proliferation and migration while suppressing apoptosis. Exploration of the mechanism by which CHPF promotes osteosarcoma indicated that CHPF promotes osteosarcoma through counteracting SKP2's ubiquitination and activating the Akt signaling pathway. For the first time

we clarified the roles of CHPF in osteosarcoma

and our results suggested that CHPF might be a novel therapeutic target in the treatment strategies for osteosarcoma.

关键词

Keywords

Akt signaling pathwayCHPFOsteosarcomaSKP2Ubiquitination

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