Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes

Hong-Yang Luo; Jie-Ying Zhu; Min Chen; Wang-Jing Mu; Liang Guo

doi:10.1016/j.gendis.2022.06.005

您当前的位置：

首页 >

文章列表页 >

Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes

Review article | 更新时间：2023-08-29

- Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes
- Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes
- Genes & Diseases 2023年10卷第3期
- 作者机构：
  
  1. Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport,Shanghai,China,200438
  2. School of Kinesiology, Shanghai University of Sport,Shanghai,China,200438
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.06.005
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-5-1，
扫描看全文
Hong-Yang Luo, Jie-Ying Zhu, Min Chen, 等. Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes[J]. Genes & Diseases, 2023,10(3).

Hong-Yang Luo, Jie-Ying Zhu, Min Chen, et al. Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes[J]. Genes & Diseases, 2023,10(3).
Hong-Yang Luo, Jie-Ying Zhu, Min Chen, 等. Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes[J]. Genes & Diseases, 2023,10(3). DOI： 10.1016/j.gendis.2022.06.005.

Hong-Yang Luo, Jie-Ying Zhu, Min Chen, et al. Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes[J]. Genes & Diseases, 2023,10(3). DOI： 10.1016/j.gendis.2022.06.005.

摘要

Abstract

Krüppel-like factor 10 (KLF10)

also known as TGFβ-inducible early gene-1 (TIEG1)

was first found in human osteoblasts. Early studies show that KLF10 plays an important role in osteogenic differentiation. Through decades of research

KLF10 has been found to have complex functions in many different cell types

and its expression and function is regulated in multiple ways. As a downstream factor of transforming growth factor β (TGFβ)/SMAD signaling

KLF10 is involved in various biological functions

including glucose and lipid metabolism in liver and adipose tissue

the maintenance of mitochondrial structure and function of the skeletal muscle

cell proliferation and apoptosis

and plays roles in multiple disease processes

such as nonalcoholic steatohepatitis (NASH) and tumor. Besides

KLF10 shows gender-dependent difference of regulation and function in many aspects. In this review

the biological functions of KLF10 and its roles in disease states is updated and discussed

which would provide new insights into the functional roles of KLF10 and a clearer view of potential therapeutic strategies by targeting KLF10.

关键词

Keywords

Adipose tissueEstrogen signalingGlucose and lipid metabolismNASHObesitySkeletal muscleTGFβ/SMAD signalingTumor

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders

The journey towards physiology and pathology: Tracing the path of neuregulin 4

New insight of obesity-associated NAFLD: Dysregulated “crosstalk” between multi-organ and the liver?

Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective

Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases