Emerging roles of circular RNAs in stem cells

Mengru Wang; Juan Wu; Pan Wu; Yuhong Li

doi:10.1016/j.gendis.2022.05.015

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Emerging roles of circular RNAs in stem cells

Review article | 更新时间：2023-08-29

- Emerging roles of circular RNAs in stem cells
- Emerging roles of circular RNAs in stem cells
- Genes & Diseases 2023年10卷第5期
- 作者机构：
  
  Department of Cell Biology, Army Medical University,Chongqing,China,400038
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.05.015
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-9-1，
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Emerging roles of circular RNAs in stem cells[J]. Genes & Diseases, 2023,10(5).

Mengru Wang, Juan Wu, Pan Wu, et al. Emerging roles of circular RNAs in stem cells[J]. Genes & Diseases, 2023,10(5).
Emerging roles of circular RNAs in stem cells[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.05.015.

Mengru Wang, Juan Wu, Pan Wu, et al. Emerging roles of circular RNAs in stem cells[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.05.015.

摘要

Abstract

Circular RNAs (circRNAs) are a novel class of noncoding RNAs that widely exist in eukaryotes. As a new focus in the field of molecular regulation

circRNAs have attracted much attention in recent years. Previous studies have confirmed that circRNAs are associated with many physiological and pathological processes. CircRNAs also participate in the regulation of stem cells. Stem cells have the properties of self-renewal and differentiation

which make stem cell therapy popular. CircRNAs may serve as new targets in stem cell therapy due to their regulation in stem cells. However

the underlying relationships between circRNAs and stem cells are still being explored. In this review

we briefly summarize the effects of circRNAs on stem cells

in the context of biological activities

aging and apoptosis

and aberrant changes. Moreover

we also examine the biological roles of stem cell-derived exosomal circRNAs. We believe our review will provide insights into the effects of circRNAs on stem cells.

关键词

Keywords

Circular RNADifferentiationProliferationStem cellStem cell-derived exosomes

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