The role of circadian clocks in cancer: Mechanisms and clinical implications

Huiwen Liu; Ying Liu; Rihan Hai; Weihua Liao; Xiangjian Luo

doi:10.1016/j.gendis.2022.05.014

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The role of circadian clocks in cancer: Mechanisms and clinical implications

Review article | 更新时间：2023-08-29

- The role of circadian clocks in cancer: Mechanisms and clinical implications
- The role of circadian clocks in cancer: Mechanisms and clinical implications
- Genes & Diseases 2023年10卷第4期
- 作者机构：
  
  1. Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan,Changsha,China,410078
  2. Department of Medicine, Hunan Traditional Chinese Medical College,Hunan,Zhuzhou,China,412000
  3. Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University,Hunan,Changsha,China,410078
  4. Molecular Imaging Research Center of Central South University,Hunan,Changsha,China,410078
  5. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Hunan,Changsha,China,410078
  6. Cancer Research Institute, School of Basic Medicine, Central South University,Hunan,Changsha,China,410078
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.05.014
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-7-1，
扫描看全文
Huiwen Liu, Ying Liu, Rihan Hai, 等. The role of circadian clocks in cancer: Mechanisms and clinical implications[J]. Genes & Diseases, 2023,10(4).

Huiwen Liu, Ying Liu, Rihan Hai, et al. The role of circadian clocks in cancer: Mechanisms and clinical implications[J]. Genes & Diseases, 2023,10(4).
Huiwen Liu, Ying Liu, Rihan Hai, 等. The role of circadian clocks in cancer: Mechanisms and clinical implications[J]. Genes & Diseases, 2023,10(4). DOI： 10.1016/j.gendis.2022.05.014.

Huiwen Liu, Ying Liu, Rihan Hai, et al. The role of circadian clocks in cancer: Mechanisms and clinical implications[J]. Genes & Diseases, 2023,10(4). DOI： 10.1016/j.gendis.2022.05.014.

摘要

Abstract

Circadian rhythm refers to the inherent 24-h cycle oscillation of biochemical

physiological and behavioral functions

which is almost universal in eukaryotes. At least 14 core clock genes have been reported to form multiple chain feedback loops that confer intrinsic circadian rhythmicity onto the molecular clock. Accumulating evidence has shown that the circadian gene dysfunction resulted from single nucleotide polymorphisms (SNPs)

deletions

epigenetic modification

and deregulation is strongly associated with cancer risk. In the present review

we describe the composition of circadian rhythm system. We highlight the function and mechanism of clock genes in cancer pathogenesis and progression. Moreover

their potential clinical implications as prognostic biomarkers and therapeutic targets have been addressed.

关键词

Keywords

CancerCancer metabolismCircadian clockCircadian rhythmChronotherapyTumor microenvironment

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