Vascular remodeling and angiogenesis are two key processes in the maintenance of vascular homeostasis and involved in a wide array of vascular pathologies. Following these processes

extracellular matrix (ECM) provides the mechanical foundation for vascular walls. Lysyl oxidase (LOX)

the key matrix-modifying enzyme

has been demonstrated to significantly affect structural abnormality and dysfunction in the blood vessels. The role of LOX in vascular remodeling and angiogenesis has always been the subject in the current medical research. Therefore

we presently make a summarization of the biosynthesis of LOX and the mechanisms involved in vascular remodeling and angiogenesis

as well as the role of LOX in diseases associated with vascular abnormalities and the therapeutic potential via targeting LOX. In particular

we give a proposal that LOX likely reshapes matrisome-associated genes expressions in the regulation of vascular remodeling and angiogenesis

which serves as a mechanistic insight into the critical role of LOX in these two aspects. Additionally

LOX has also dual effects on the vascular dysfunction

namely

inhibition of LOX for improving hypertension

restenosis and malignant tumor while activation of LOX for curing arterial aneurysm and dissection. LOX-targeted therapy may provide a promising therapeutic strategy for the treatment of various vascular pathologies associated with vascular remodeling and angiogenesis.