Hydrogen sulfide-induced post-translational modification as a potential drug target

Hao-Jie Chen; Lei Qian; Ke Li; Yang-Zhe Qin; Jing-Jing Zhou; Xin-Ying Ji; Dong-Dong Wu

doi:10.1016/j.gendis.2022.03.022

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Hydrogen sulfide-induced post-translational modification as a potential drug target

Review article | 更新时间：2023-08-29

- Hydrogen sulfide-induced post-translational modification as a potential drug target
- Hydrogen sulfide-induced post-translational modification as a potential drug target
- Genes & Diseases 2023年10卷第5期
- 作者机构：
  
  1. Kaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University,Henan,Kaifeng,China,475004
  2. School of Basic Medical Sciences, Henan University,Henan,Kaifeng,China,475004
  3. School of Stomatology, Henan University,Henan,Kaifeng,China,475004
  4. Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University,Henan,Kaifeng,China,475004
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.03.022
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-9-1，
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Hao-Jie Chen, Lei Qian, Ke Li, 等. Hydrogen sulfide-induced post-translational modification as a potential drug target[J]. Genes & Diseases, 2023,10(5).

Hao-Jie Chen, Lei Qian, Ke Li, et al. Hydrogen sulfide-induced post-translational modification as a potential drug target[J]. Genes & Diseases, 2023,10(5).
Hao-Jie Chen, Lei Qian, Ke Li, 等. Hydrogen sulfide-induced post-translational modification as a potential drug target[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.03.022.

Hao-Jie Chen, Lei Qian, Ke Li, et al. Hydrogen sulfide-induced post-translational modification as a potential drug target[J]. Genes & Diseases, 2023,10(5). DOI： 10.1016/j.gendis.2022.03.022.

摘要

Abstract

Hydrogen sulfide (H

S) is one of the three known gas signal transducers

and since its potential physiological role was reported

the literature on H

S has been increasing. H

S is involved in processes such as vasodilation

neurotransmission

angiogenesis

inflammation

and the prevention of ischemia-reperfusion injury

and its mechanism remains to be further studied. At present

the role of post-translational processing of proteins has been considered as a possible mechanism for the involvement of H

S in a variety of physiological processes. Current studies have shown that H

S is involved in S-sulfhydration

phosphorylation

and S-nitrosylation of proteins

etc. This paper focuses on the effects of protein modification involving H

S on physiological and pathological processes

looking forward to providing guidance for subsequent research.

关键词

Keywords

Hydrogen sulfideModificationPhosphorylationS-nitrosylationS-sulfhydration

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