Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities

Guo Zhao; Junfeng Zhen; Xinyuan Liu; Jinshuai Guo; Duanduan Li; Jianping Xie; Longxiang Xie

doi:10.1016/j.gendis.2022.03.009

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Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities

Review article | 更新时间：2023-08-29

- Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities
- Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities
- Genes & Diseases 2023年10卷第4期
- 作者机构：
  
  1. Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University,Henan,Kaifeng,China,475004
  2. State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Institute of Modern Biopharmaceuticals, Ministry of Education, School of Life Sciences, Southwest University,Chongqing,China,400715
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.03.009
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-7-1，
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Guo Zhao, Junfeng Zhen, Xinyuan Liu, 等. Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities[J]. Genes & Diseases, 2023,10(4).

Guo Zhao, Junfeng Zhen, Xinyuan Liu, et al. Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities[J]. Genes & Diseases, 2023,10(4).
Guo Zhao, Junfeng Zhen, Xinyuan Liu, 等. Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities[J]. Genes & Diseases, 2023,10(4). DOI： 10.1016/j.gendis.2022.03.009.

Guo Zhao, Junfeng Zhen, Xinyuan Liu, et al. Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities[J]. Genes & Diseases, 2023,10(4). DOI： 10.1016/j.gendis.2022.03.009.

摘要

Abstract

Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism physiology and some pathophysiological processes

such as tumorigenesis and metabolic diseases. To provide an understanding of the molecular mechanism and functions of Ksuc in different organisms

we reviewed the current literature about Ksuc

mainly summarizing the research advances in eukaryotes and prokaryotes based on both traditional study methods and site prediction tools. We also discussed inhibitors or activators associated with Ksuc that may contribute to proteomic studies and could be useful in future clinical practice. A deeper understanding of Ksuc may shed new light on life science at the protein level and could lead to novel therapeutic strategies for various diseases.

关键词

Keywords

DiseaseEukaryotesLysine succinylationPhysiologyProkaryotesProtein post-translational modification

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