Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer

Abhijit Das; Barshana Bhattacharya; Souvik Roy

doi:10.1016/j.gendis.2021.12.025

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Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer

Review article | 更新时间：2022-06-24

- Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer
- Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer
- Genes & Diseases 2022年9卷第4期
- 作者机构：
  
  Department of Pharmacology, NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata,India,700053
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.12.025
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-7-1，
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Abhijit Das, Barshana Bhattacharya, Souvik Roy. Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer[J]. Genes & Diseases, 2022,9(4).

Abhijit Das, Barshana Bhattacharya, Souvik Roy. Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer[J]. Genes & Diseases, 2022,9(4).
Abhijit Das, Barshana Bhattacharya, Souvik Roy. Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer[J]. Genes & Diseases, 2022,9(4). DOI： 10.1016/j.gendis.2021.12.025.

Abhijit Das, Barshana Bhattacharya, Souvik Roy. Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer[J]. Genes & Diseases, 2022,9(4). DOI： 10.1016/j.gendis.2021.12.025.

摘要

Abstract

Cancer is one of those leading diseases worldwide

which takes millions of lives every year. Researchers are continuously looking for specific approaches to eradicate the deadly disease

ensuring minimal adverse effects along with more therapeutic significance. Targeting of different aberrantly regulated signaling pathways

involved in cancer

is surely one of the revolutionary chemotherapeutic approach. In this instance

GSK3 and PI3K signaling cascades are considered as important role player for both the oncogenic activation and inactivation which further leads to cancer proliferation and metastasis. In this review

we have discussed the potential role of GSK3 and PI3K signaling in cancer

and we further established the crosstalk between PI3K and GSK3 signaling

through showcasing their cross activation

cross inhibition and convergence pathways in association with cancer. We also exhibited the effect of GSK3 on the efficacy of PI3K inhibitors to overcome the drug resistance and preventing the cell proliferation

metastasis in a combinatorial way with GSK3 inhibitors for a better treatment strategy in clinical settings.

关键词

Keywords

CancerChemotherapyDrug resistanceGSK3PI3K

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