LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy

Xin Huang; Weiyue Zhang; Feifei Pu; Zhicai Zhang

doi:10.1016/j.gendis.2021.11.004

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LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy

Full-length article | 更新时间：2023-05-16

- LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy
- LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy
- Genes & Diseases 2023年10卷第2期
- 作者机构：
  
  1. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China,430022
  2. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China,430022
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.11.004
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-3-1，
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LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy[J]. Genes & Diseases, 2023,10(2).

Xin Huang, Weiyue Zhang, Feifei Pu, et al. LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy[J]. Genes & Diseases, 2023,10(2).
LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy[J]. Genes & Diseases, 2023,10(2). DOI： 10.1016/j.gendis.2021.11.004.

Xin Huang, Weiyue Zhang, Feifei Pu, et al. LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy[J]. Genes & Diseases, 2023,10(2). DOI： 10.1016/j.gendis.2021.11.004.

摘要

Abstract

This study aimed to investigate the role of long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) in chemosensitivity of osteosarcoma (OS)

and to reveal the possible underlying mechanisms. In this study

we found that the expression of lncRNA MEG3 was significantly lower in OS tissues and cell lines. Furthermore

lncRNA MEG3 overexpression enhanced chemosensitivity of OS by inhibiting cell proliferation

migration

autophagy

and promoting antitumor immunity. LncRNA MEG3 functioned as miR-21-5 sponge to regulate p53 expression in OS. Mechanically

lncRNA MEG3 promoted OS chemosensitivity by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy. Collectively

this study provided the evidence that lncRNA MEG3 might be a promising therapeutic target for OS chemoresistance.

关键词

Keywords

Antitumor immunityAutophagyChemosensitivityLncRNAMEG3Osteosarcoma

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