Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response

Yuanliang Yan; Jinwu Peng; Qiuju Liang; Xinxin Ren; Yuan Cai; Bi Peng; Xi Chen; Xiang Wang; Qiaoli Yi; Zhijie Xu

doi:10.1016/j.gendis.2021.10.004

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Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response

Review article | 更新时间：2023-08-29

- Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response
- Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response
- Genes & Diseases 2023年10卷第1期
- 作者机构：
  
  1. Department of Pharmacy, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  2. Department of Pathology, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  3. Department of Pathology, Xiangya Changde Hospital,Hunan,Changde,China,415000
  4. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  5. Center for Molecular Medicine, Xiangya Hospital, Key Laboratory of Molecular Radiation Oncology of Hunan Province, Central South University,Hunan,Changsha,China,410008
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.10.004
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-1-1，
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Yuanliang Yan, Jinwu Peng, Qiuju Liang, 等. Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response[J]. Genes & Diseases, 2023,10(1).

Yuanliang Yan, Jinwu Peng, Qiuju Liang, et al. Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response[J]. Genes & Diseases, 2023,10(1).
Yuanliang Yan, Jinwu Peng, Qiuju Liang, 等. Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.10.004.

Yuanliang Yan, Jinwu Peng, Qiuju Liang, et al. Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.10.004.

摘要

Abstract

Several types of modifications have been proven to participate in the metabolism and processing of different RNA types

including non-coding RNAs (ncRNAs). N-6-methyladenosine (m6A) is a dynamic and reversible RNA modification that is closely involved in the ncRNA homeostasis

and serves as a crucial regulator for multiple cancer-associated signaling pathways. The ncRNAs usually regulate the epigenetic modification

mRNA transcription and other biological processes

displaying enormous roles in human cancers. In this review

we summarized the significant implications of m6A-ncRNA interaction in various types of cancers. In particular

the interplay between m6A and ncRNAs in cancer pathogenesis and therapeutic resistance are being widely recognized. We also discussed the relevance of m6A-ncRNA interaction in immune regulation

followed by the interference on cancer immunotherapeutic procedures. In addition

we briefly highlighted the computation tools that could identify the accurate features of m6A methylome among ncRNAs. In summary

this review would pave the way for a better understanding of the biological functions of m6A-ncRNA crosstalk in cancer research and treatment.

关键词

Keywords

CancerImmune regulationN-6-MethyladenosineNon-coding RNAsTherapeutic response

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