Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies

Xinghan Liu; Lijie Yin; Sunan Shen; Yayi Hou

doi:10.1016/j.gendis.2021.09.006

您当前的位置：

首页 >

文章列表页 >

Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies

Review article | 更新时间：2023-08-29

- Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies
- Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies
- Genes & Diseases 2023年10卷第1期
- 作者机构：
  
  1. The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University,Jiangsu,Nanjing,China,210093
  2. Jiangsu Key Laboratory of Molecular Medicine, Nanjing University,Jiangsu,Nanjing,China,210093
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.09.006
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-1-1，
扫描看全文
Xinghan Liu, Lijie Yin, Sunan Shen, 等. Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies[J]. Genes & Diseases, 2023,10(1).

Xinghan Liu, Lijie Yin, Sunan Shen, et al. Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies[J]. Genes & Diseases, 2023,10(1).
Xinghan Liu, Lijie Yin, Sunan Shen, 等. Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.09.006.

Xinghan Liu, Lijie Yin, Sunan Shen, et al. Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.09.006.

摘要

Abstract

Chronic inflammation caused by persistent infections and metabolic disorders is thought to contribute to the increased cancer risk and the accelerated cancer progression. Oppositely

acute inflammation induced by bacteria-based vaccines or that is occurring after cancer selectively inhibits cancer progression and metastasis. However

the interaction between inflammation and cancer may be more complex than the current explanations for the relationship between chronic and acute inflammation and cancer. In this review

we described the impact of inflammation on cancer on the basis of three perspectives

including inflammation with different durations (chronic and acute inflammation)

different scopes (systemic and local inflammation) and different occurrence sequences (inflammation occurring after and before cancer). In addition

we also introduced bacteria/virus-based cancer immunotherapies. We perceive that inflammation may be a double-edged sword with cancer-promoting and cancer-suppressing functions in certain cases. We expect to further improve the understanding of the relationship between inflammation and cancer and provide a theoretical basis for further research on their complex interaction.

关键词

Keywords

CancerDurationInflammationScopeSequence

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

The emerging role of Arid5a in cancer: A new target for tumors

The emerging role of snoRNAs in human disease

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

De novo nucleotide biosynthetic pathway and cancer

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers