mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases

Siyao Guo; Shuibin Lin

doi:10.1016/j.gendis.2021.09.005

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mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases

Review article | 更新时间：2023-08-29

- mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases
- mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases
- Genes & Diseases 2023年10卷第1期
- 作者机构：
  
  1. Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University,Guangdong,Guangzhou,China,510080
  2. State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center,Guangdong,Guangzhou,China,510060
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.09.005
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-1-1，
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Siyao Guo, Shuibin Lin. mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases[J]. Genes & Diseases, 2023,10(1).

Siyao Guo, Shuibin Lin. mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases[J]. Genes & Diseases, 2023,10(1).
Siyao Guo, Shuibin Lin. mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.09.005.

Siyao Guo, Shuibin Lin. mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.09.005.

摘要

Abstract

The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase

poly(A) tail is synthesized after the polyadenylation signal (PAS) sites on the mRNAs. Alternative polyadenylation (APA) often occurs in mRNAs with multiple poly(A) sites

producing different 3′ ends for transcript variants

and therefore plays important functions in gene expression regulation. In this review

we first summarize the classical process of mRNA 3′-terminal formation and discuss the length control mechanisms of poly(A) in nucleus and cytoplasm. Then we review the research progress on alternative polyadenylation regulation and the APA site selection mechanism. Finally

we summarize the functional roles of APA in the regulation of gene expression and diseases including cancers.

关键词

Keywords

Alternative polyadenylation (APA)CancerGene expressionmRNA polyadenylationPoly(A)

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