Adipose-derived stem cells and obesity: The spear and shield relationship

Hong Yang; Chaowei Li; Yizhou Li; Ruiqing Tai; Chao Sun

doi:10.1016/j.gendis.2021.09.004

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Adipose-derived stem cells and obesity: The spear and shield relationship

Review article | 更新时间：2023-08-29

- Adipose-derived stem cells and obesity: The spear and shield relationship
- Adipose-derived stem cells and obesity: The spear and shield relationship
- Genes & Diseases 2023年10卷第1期
- 作者机构：
  
  Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling,Shaanxi,China,712100
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.09.004
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-1-1，
扫描看全文
Adipose-derived stem cells and obesity: The spear and shield relationship[J]. Genes & Diseases, 2023,10(1).

Hong Yang, Chaowei Li, Yizhou Li, et al. Adipose-derived stem cells and obesity: The spear and shield relationship[J]. Genes & Diseases, 2023,10(1).
Adipose-derived stem cells and obesity: The spear and shield relationship[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.09.004.

Hong Yang, Chaowei Li, Yizhou Li, et al. Adipose-derived stem cells and obesity: The spear and shield relationship[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.09.004.

摘要

Abstract

With the transformation of modern lifestyles and population ageing

obesity has become a global epidemic

as one of the important threat to human health of chronic non-communicable diseases (NCD). Stem cell therapy seems promising as an alternative strategy for managing obesity and related metabolic problems. Adipose tissue-derived stem cells (ADSCs) have received widespread attention

which provides new ideas for the treatment of obesity and various metabolic-related diseases

due to their abundant reserves

easy acquisition

rapid expansion

and multi-directional differentiation potential

low immunogenicity and many other advantages. Accordingly

there seems to be a “shield and spear paradox” in the relationship between ADSCs and obesity. In this review

we emphatically summarized the role of ADSCs in the occurrence and development of obesity and related metabolic disease processes

in order to pave the way for clinical practice.

关键词

Keywords

Adipose-derived stem cellsDifferentiationInflammationInsulin resistanceMetabolic syndromeObesity

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