CCL5/CCR5 axis in human diseases and related treatments

Zhen Zeng; Tianxia Lan; Yuquan Wei; Xiawei Wei

doi:10.1016/j.gendis.2021.08.004

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CCL5/CCR5 axis in human diseases and related treatments

Review article | 更新时间：2022-06-24

- CCL5/CCR5 axis in human diseases and related treatments
- CCL5/CCR5 axis in human diseases and related treatments
- Genes & Diseases 2022年9卷第1期
- 作者机构：
  
  Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road,Sichuan,Chengdu,PR China,610041
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.08.004
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-1-1，
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Zhen Zeng, Tianxia Lan, Yuquan Wei, 等. CCL5/CCR5 axis in human diseases and related treatments[J]. Genes & Diseases, 2022,9(1).

Zhen Zeng, Tianxia Lan, Yuquan Wei, et al. CCL5/CCR5 axis in human diseases and related treatments[J]. Genes & Diseases, 2022,9(1).
Zhen Zeng, Tianxia Lan, Yuquan Wei, 等. CCL5/CCR5 axis in human diseases and related treatments[J]. Genes & Diseases, 2022,9(1). DOI： 10.1016/j.gendis.2021.08.004.

Zhen Zeng, Tianxia Lan, Yuquan Wei, et al. CCL5/CCR5 axis in human diseases and related treatments[J]. Genes & Diseases, 2022,9(1). DOI： 10.1016/j.gendis.2021.08.004.

摘要

Abstract

To defense harmful stimuli or maintain the immune homeostasis

the body produces and recruits a superfamily of cytokines such as interleukins

interferons

chemokines etc. Among them

chemokines act as crucial regulators in defense systems. CCL5/CCR5 combination is known for facilitating inflammatory responses

as well as inducing the adhesion and migration of different T cell subsets in immune responses. In addition

recent studies have shown that the interaction between CCL5 and CCR5 is involved in various pathological processes including inflammation

chronic diseases

cancers as well as the infection of COVID-19. This review focuses on how CCL5/CCR5 axis participates in the pathological processes of different diseases and their relevant signaling pathways for the regulation of the axis. Moreover

we highlighted the gene therapy and chemotherapy studies for treating CCR5-related diseases

including the ongoing clinical trials. The barriers and perspectives for future application and translational research were also summarized.

关键词

Keywords

CancerCCL5/CCR5InfectionTherapy

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