Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

Wencheng Kong; Guang Yin; Sixin Zheng; Xinchun Liu; Akao Zhu; Panpan Yu; Jian Zhang; Yuqiang Shan; Rongchao Ying; Huicheng Jin

doi:10.1016/j.gendis.2021.07.006

您当前的位置：

首页 >

文章列表页 >

Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

Review article | 更新时间：2022-08-11

- Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
- Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
- Genes & Diseases 2022年9卷第5期
- 作者机构：
  
  Department of Gastroenterological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine,Zhejiang,Hangzhou,PR China,310006
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.07.006
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-9-1，
扫描看全文
Wencheng Kong, Guang Yin, Sixin Zheng, 等. Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer[J]. Genes & Diseases, 2022,9(5).

Wencheng Kong, Guang Yin, Sixin Zheng, et al. Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer[J]. Genes & Diseases, 2022,9(5).
Wencheng Kong, Guang Yin, Sixin Zheng, 等. Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer[J]. Genes & Diseases, 2022,9(5). DOI： 10.1016/j.gendis.2021.07.006.

Wencheng Kong, Guang Yin, Sixin Zheng, et al. Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer[J]. Genes & Diseases, 2022,9(5). DOI： 10.1016/j.gendis.2021.07.006.

摘要

Abstract

Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors

leading to genomic stability

proliferation

survival

invasion

migration

metastasis

and drug resistance. In the present article

we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer

whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes

leading to the development of potential therapeutic strategies.

关键词

Keywords

ExpressionGastric cancerHOTAIR regulationRegulatory pathways

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects

PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway

The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses