Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury

Almaz Zaki; M. Shadab Ali; Vijay Hadda; Syed Mansoor Ali; Anita Chopra; Tasneem Fatma

doi:10.1016/j.gendis.2021.07.004

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Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury

Review article | 更新时间：2022-08-11

- Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury
- Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury
- Genes & Diseases 2022年9卷第5期
- 作者机构：
  
  1. Department of Biosciences, Jamia Millia Islamia University,New Delhi,India,110025
  2. Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences,New Delhi,India,110029
  3. Department of Biotechnology, Jamia Millia Islamia University,New Delhi,India,110025
  4. Lab Oncology, Dr. BRA-IRCH, All India Institute of Medical Sciences,New Delhi,India,110029
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.07.004
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-9-1，
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Almaz Zaki, M. Shadab Ali, Vijay Hadda, 等. Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury[J]. Genes & Diseases, 2022,9(5).

Almaz Zaki, M. Shadab Ali, Vijay Hadda, et al. Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury[J]. Genes & Diseases, 2022,9(5).
Almaz Zaki, M. Shadab Ali, Vijay Hadda, 等. Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury[J]. Genes & Diseases, 2022,9(5). DOI： 10.1016/j.gendis.2021.07.004.

Almaz Zaki, M. Shadab Ali, Vijay Hadda, et al. Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury[J]. Genes & Diseases, 2022,9(5). DOI： 10.1016/j.gendis.2021.07.004.

摘要

Abstract

ute Lung Injury (ALI) and its severe form Acute Respiratory Distress Syndrome (ARDS) are the major cause of ICU death worldwide. ALI/ARDS is characterized by severe hypoxemia and inflammation that leads to poor lung compliance. Despite many advances in understanding and management

ALI/ARDS is still causing significant morbidity and mortality. Long non-coding RNA (lncRNA) is a fast-growing topic in lung inflammation and injury. lncRNA is a class of non-coding RNA having a length of more than 200 nucleotides. It has been a center of research for understanding the pathophysiology of various diseases in the past few years. Multiple studies have shown that lncRNAs are abundant in acute lung injury/injuries in mouse models and cell lines. By targeting these long non-coding RNAs

many investigators have demonstrated the alleviation of ALI in various mouse models. Therefore

lncRNAs show great promise as a therapeutic target in ALI. This review provides the current state of knowledge about the relationship between lncRNAs in various biological processes in acute lung injury and its use as a potential therapeutic target.

关键词

Keywords

Acute lung injuryApoptosisInflammationLong non-coding RNA (lncRNA)Macrophage polarization

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