The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications

Liu Yang; Guohong Liu; Yirong Li; Yunbao Pan

doi:10.1016/j.gendis.2021.07.002

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The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications

Review article | 更新时间：2022-08-11

- The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications
- The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications
- Genes & Diseases 2022年9卷第5期
- 作者机构：
  
  1. Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University,Hubei,Wuhan,PR China,430071
  2. Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University,Hubei,Wuhan,PR China,430071
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.07.002
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-9-1，
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Liu Yang, Guohong Liu, Yirong Li, 等. The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications[J]. Genes & Diseases, 2022,9(5).

Liu Yang, Guohong Liu, Yirong Li, et al. The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications[J]. Genes & Diseases, 2022,9(5).
Liu Yang, Guohong Liu, Yirong Li, 等. The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications[J]. Genes & Diseases, 2022,9(5). DOI： 10.1016/j.gendis.2021.07.002.

Liu Yang, Guohong Liu, Yirong Li, et al. The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications[J]. Genes & Diseases, 2022,9(5). DOI： 10.1016/j.gendis.2021.07.002.

摘要

Abstract

The clinical study of nasopharyngeal carcinoma (NPC) often reveals a large number of lymphocytes infiltrating the primary tumor site. As an important part of the tumor microenvironment

tumor-infiltrating lymphocytes (TILs) do not exist alone but as a complex multicellular population with high heterogeneity. TILs play an extremely significant role in the occurrence

development

invasion and metastasis of NPC. The latest research shows that they participate in tumorigenesis and treatment

and the composition

quantity

functional status and distribution of TILs subsets have good predictive value for the prognosis of NPC patients. TILs are an independent prognostic factor for TNM stage and significantly correlated with better prognosis. Additionally

adoptive immunotherapy using anti-tumor TILs has achieved good results in a variety of solid tumors including NPC. This review evaluates recent clinical and preclinical studies of NPC

summarizes the role of TILs in promoting and inhibiting tumor growth

evaluates the predictive value of TILs

and explores the potential benefits of TILs-based immunotherapy in the treatment of NPC.

关键词

Keywords

Nasopharyngeal carcinomaNPC microenvironmentTumor-infiltrating lymphocyteTumor immunotherapyTumor prognosis

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Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma