Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma

Xiaofeng Zuo; Peixin Meng; Yuxin Bao; Chuntao Tao; Yitao Wang; Xianjun Liu; Youquan Bu; Jiang Zhu

doi:10.1016/j.gendis.2021.05.003

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Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma

Full-length article | 更新时间：2023-08-29

- Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma
- Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma
- Genes & Diseases 2023年10卷第1期
- 作者机构：
  
  1. Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University,Chongqing,China,400016
  2. Department of Biochemistry and Molecular Biology, Chongqing Medical University,Chongqing,China,400016
  3. Molecular Medicine and Cancer Research Center, Chongqing Medical University,Chongqing,China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.05.003
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-1-1，
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Xiaofeng Zuo, Peixin Meng, Yuxin Bao, 等. Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma[J]. Genes & Diseases, 2023,10(1).

Xiaofeng Zuo, Peixin Meng, Yuxin Bao, et al. Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma[J]. Genes & Diseases, 2023,10(1).
Xiaofeng Zuo, Peixin Meng, Yuxin Bao, 等. Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.05.003.

Xiaofeng Zuo, Peixin Meng, Yuxin Bao, et al. Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma[J]. Genes & Diseases, 2023,10(1). DOI： 10.1016/j.gendis.2021.05.003.

摘要

Abstract

Nasopharyngeal carcinoma (NPC) is a common malignant carcinoma of the head and neck

and the biological mechanisms underlying the pathogenesis of NPC remain not fully understood. In the present study

we systematically analyzed four independent NPC transcriptomic datasets and focused on identifying the critical molecular networks and novel key hub genes implicated in NPC. We found totally 170 common overlapping differentially expressed genes (DEGs) in the four NPC datasets. GO and KEGG pathway analysis revealed that cell cycle dysregulation is a critical event in NPC. Protein–protein interaction (PPI) network analysis identified a 15 hub-gene core network with overexpressed kinesin family member 2C (KIF2C) as a central regulator. Loss-of-function study demonstrated that knockdown of KIF2C significantly inhibited cell growth and cell motility

and delayed cell cycle progression

accompanied with dramatic mitotic defects in spindle formation in NPC cells. RNA-seq analysis revealed that KIF2C knockdown led to deregulation of various downstream genes. KIF2C could also regulate the AKT/mTOR pathways

and enhance paclitaxel sensitivity in NPC cells. Taken together

our results suggest that cell cycle dysregulation is a critical event during NPC pathogenesis and KIF2C is a novel key mitotic hub gene with therapeutic potential in NPC.

关键词

Keywords

BioinformaticsCell cycleKIF2CMitosisNasopharyngeal carcinoma

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