Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy

Meilin Chen; Yijun Liu; Yuqin Yang; Yanbing Qiu; Zhicheng Wang; Xiaoxu Li; Wenling Zhang

doi:10.1016/j.gendis.2021.04.008

您当前的位置：

首页 >

文章列表页 >

Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy

Review article | 更新时间：2022-06-24

- Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy
- Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy
- Genes & Diseases 2022年9卷第4期
- 作者机构：
  
  Department of Medical Laboratory Science, The Third Xiangya Hospital, Central South University,Hunan,Changsha,PR China,410013
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.04.008
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-7-1，
扫描看全文
Meilin Chen, Yijun Liu, Yuqin Yang, 等. Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy[J]. Genes & Diseases, 2022,9(4).

Meilin Chen, Yijun Liu, Yuqin Yang, et al. Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy[J]. Genes & Diseases, 2022,9(4).
Meilin Chen, Yijun Liu, Yuqin Yang, 等. Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy[J]. Genes & Diseases, 2022,9(4). DOI： 10.1016/j.gendis.2021.04.008.

Meilin Chen, Yijun Liu, Yuqin Yang, et al. Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy[J]. Genes & Diseases, 2022,9(4). DOI： 10.1016/j.gendis.2021.04.008.

摘要

Abstract

ivating transcription factors

ATFs

are a group of bZIP transcription factors that act as homodimers or heterodimers with a range of other bZIP factors. In general

ATFs respond to extracellular signals

indicating their important roles in maintaining homeostasis. The ATF family includes ATF1

ATF2

ATF3

ATF4

ATF5

ATF6

and ATF7. Consistent with the diversity of cellular processes reported to be regulated by ATFs

the functions of ATFs are also diverse. ATFs play an important role in cell proliferation

apoptosis

differentiation and inflammation-related pathological processes. The expression and phosphorylation status of ATFs are also related to neurodegenerative diseases and polycystic kidney disease. Various miRNAs target ATFs to regulate cancer proliferation

apoptosis

autophagy

sensitivity and resistance to radiotherapy and chemotherapy. Moreover

ATFs are necessary to maintain cell redox homeostasis. Therefore

deepening our understanding of the regulation and function of ATFs will provide insights into the basic regulatory mechanisms that influence how cells integrate extracellular and intracellular signals into genomic responses through transcription factors. Under pathological conditions

especially in cancer biology and response to treatment

the characterization of ATF dysfunction is important for understanding how to therapeutically utilize ATF2 or other pathways controlled by transcription factors. In this review

we will demonstrate how ATF1

ATF2

ATF3

ATF4

ATF5

ATF6

and ATF7 function in promoting or suppressing cancer development and identify their roles in tumour immunotherapy.

关键词

Keywords

Anti-tumor effectATFbZIPCancerImmunityTumorigenesis

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

De novo nucleotide biosynthetic pathway and cancer

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

The generation and use of animal models of osteosarcoma in cancer research