Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration

Sheng Zhou; Song Chen; Yixuan Amy Pei; Ming Pei

doi:10.1016/j.gendis.2021.03.004

您当前的位置：

首页 >

文章列表页 >

Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration

Review article | 更新时间：2022-06-24

- Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration
- Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration
- Genes & Diseases 2022年9卷第3期
- 作者机构：
  
  1. Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown,WV,USA,26506
  2. Department of Orthopaedics, The General Hospital of Western Theater Command,Sichuan,Chengdu,PR China,610083
  3. WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown,WV,USA,26506
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.03.004
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-5-1，
扫描看全文
Sheng Zhou, Song Chen, Yixuan Amy Pei, 等. Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration[J]. Genes & Diseases, 2022,9(3).

Sheng Zhou, Song Chen, Yixuan Amy Pei, et al. Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration[J]. Genes & Diseases, 2022,9(3).
Sheng Zhou, Song Chen, Yixuan Amy Pei, 等. Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration[J]. Genes & Diseases, 2022,9(3). DOI： 10.1016/j.gendis.2021.03.004.

Sheng Zhou, Song Chen, Yixuan Amy Pei, et al. Nidogen: A matrix protein with potential roles in musculoskeletal tissue regeneration[J]. Genes & Diseases, 2022,9(3). DOI： 10.1016/j.gendis.2021.03.004.

摘要

Abstract

Basement membrane proteins are known to guide cell structures

differentiation

and tissue repair. Although there is a wealth of knowledge on the functions of laminins

perlecan

and type IV collagen in maintaining tissue homeostasis

not much is known about nidogen. As a key molecule in the basement membrane

nidogen contributes to the formation of a delicate microenvironment that proves necessary for stem cell lineage-specific differentiation. In this review

the expression of nidogen is delineated at both cellular and tissue levels from embryonic to adult stages of development; the effect of nidogens is also summarized in the context of musculoskeletal development and regeneration

including but not limited to adipogenesis

angiogenesis

chondrogenesis

myogenesis

and neurogenesis. Furthermore

potential mechanisms underlying the role of nidogens in stem cell-based tissue regeneration are also discussed. This concise review is expected to facilitate our existing understanding and utilization of nidogen in tissue engineering and regeneration.

关键词

Keywords

AdiposeBasement membraneCartilageDifferentiationNerveNidogensVessel

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma

Emerging roles of circular RNAs in stem cells

Adipose-derived stem cells and obesity: The spear and shield relationship

All-trans retinoic acid reverses malignant biological behavior of hepatocarcinoma cells by regulating miR-200 family members