Calcineurin in development and disease

Lei Chen; Min Song; Chunyan Yao

doi:10.1016/j.gendis.2021.03.002

您当前的位置：

首页 >

文章列表页 >

Calcineurin in development and disease

Review article | 更新时间：2022-06-24

- Calcineurin in development and disease
- Calcineurin in development and disease
- Genes & Diseases 2022年9卷第4期
- 作者机构：
  
  Department of Blood Transfusion, First Affiliated Hospital, The Third Military Medical University (Army Medical University),Chongqing,PR China,400038
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.03.002
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-7-1，
扫描看全文
Lei Chen, Min Song, Chunyan Yao. Calcineurin in development and disease[J]. Genes & Diseases, 2022,9(4).

Lei Chen, Min Song, Chunyan Yao. Calcineurin in development and disease[J]. Genes & Diseases, 2022,9(4).
Lei Chen, Min Song, Chunyan Yao. Calcineurin in development and disease[J]. Genes & Diseases, 2022,9(4). DOI： 10.1016/j.gendis.2021.03.002.

Lei Chen, Min Song, Chunyan Yao. Calcineurin in development and disease[J]. Genes & Diseases, 2022,9(4). DOI： 10.1016/j.gendis.2021.03.002.

摘要

Abstract

Calcineurin (CaN) is a unique calcium (Ca

) and calmodulin (CaM)-dependent serine/threonine phosphatase that becomes activated in the presence of increased intracellular Ca

level. CaN then functions to dephosphorylate target substrates including various transcription factors

receptors

and channels. Once activated

the CaN signaling pathway participates in the development of multiple organs as well as the onset and progression of various diseases via regulation of different cellular processes. Here

we review current literature regarding the structural and functional properties of CaN

highlighting its crucial role in the development and pathogenesis of immune system disorders

neurodegenerative diseases

kidney disease

cardiomyopathy and cancer.

关键词

Keywords

CalcineurinCancerCardiomyopathyDevelopmentImmune system diseaseKidney diseaseNeurodegeneration

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

De novo nucleotide biosynthetic pathway and cancer

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

The generation and use of animal models of osteosarcoma in cancer research

The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities