Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease

Liping Xiang; Yang Jiao; Yiling Qian; Yao Li; Fei Mao; Yan Lu

doi:10.1016/j.gendis.2021.02.008

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Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease

Full-length article | 更新时间：2022-06-24

- Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease
- Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease
- Genes & Diseases 2022年9卷第1期
- 作者机构：
  
  1. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University,Shanghai,PR China,200032
  2. Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University,Shanghai,PR China,200032
  3. Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine,Shanghai,PR China,200025
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2021.02.008
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-1-1，
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Liping Xiang, Yang Jiao, Yiling Qian, 等. Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease[J]. Genes & Diseases, 2022,9(1).

Liping Xiang, Yang Jiao, Yiling Qian, et al. Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease[J]. Genes & Diseases, 2022,9(1).
Liping Xiang, Yang Jiao, Yiling Qian, 等. Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease[J]. Genes & Diseases, 2022,9(1). DOI： 10.1016/j.gendis.2021.02.008.

Liping Xiang, Yang Jiao, Yiling Qian, et al. Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease[J]. Genes & Diseases, 2022,9(1). DOI： 10.1016/j.gendis.2021.02.008.

摘要

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder worldwide. Murine models of NAFLD have been widely used to explore its pathogenesis. In this study

we performed a systematic evaluation of hepatic genome-wide mRNA expression by RNA-Sequencing using three mouse models of NAFLD: leptin receptor deficient db/db mice

high-fat high-sugar diet (HSHF)-induced obese mice

and dexamethasone (DEX)-induced NAFLD mice. As a result

we found both distinct and common pathways in the regulation of lipid metabolism from transcriptomes of three mouse models. Moreover

only a total of 12 differentially expressed genes (DEGs) were commonly detected among all three mouse groups

indicating very little overlap among all three models. Therefore

our results suggest that NAFLD is a heterogeneous disease with highly variable molecular mechanisms.

关键词

Keywords

DEGsMurine modelsNAFLDPathway analysisTranscriptome

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