Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies

Shenglong Li; Wang Wang; Tingting Li; Xiaojian Han; Chao Hu; Yingming Wang; Meiying Shen; Li Du; Yaru Nai; Jianwei Wang; Aishun Jin

doi:10.1016/j.gendis.2020.12.007

您当前的位置：

首页 >

文章列表页 >

Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies

Full-length article | 更新时间：2022-06-24

- Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies
- Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies
- Genes & Diseases 2022年9卷第2期
- 作者机构：
  
  1. Department of Immunology, College of Basic Medicine, Chongqing Medical University,Chongqing,PR China,400016
  2. Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University,Chongqing,PR China,400016
  3. Department of Breast Surgery, Harbin Medical University Cancer Hospital,Harbin,PR China,150081
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.12.007
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-3-1，
扫描看全文
Shenglong Li, Wang Wang, Tingting Li, 等. Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies[J]. Genes & Diseases, 2022,9(2).

Shenglong Li, Wang Wang, Tingting Li, et al. Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies[J]. Genes & Diseases, 2022,9(2).
Shenglong Li, Wang Wang, Tingting Li, 等. Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies[J]. Genes & Diseases, 2022,9(2). DOI： 10.1016/j.gendis.2020.12.007.

Shenglong Li, Wang Wang, Tingting Li, et al. Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies[J]. Genes & Diseases, 2022,9(2). DOI： 10.1016/j.gendis.2020.12.007.

摘要

Abstract

The pandemic of COVID-19 caused by SARS-CoV-2 has made serious threats to the public health. Antibodies have been considered as promising therapeutics for the prevention and treatment of pathogens. So far

effectors that can influence the sustainability of SARS-CoV-2 specific antibodies in COVID-19 patients are still unclear. In this paper

we attempted to find potential key factors correlated with SARS-CoV-2 specific antibodies. Transcriptional analysis with the peripheral blood mononuclear cells (PBMCs) revealed proportional changes of immune cell subsets in COVID-19 convalescent patients

including a substantial decrease of monocytes and evident increase of dendritic cells (DCs). Moreover

we found that the gene expressions of chemokines associated with monocyte/macrophage were significantly up-regulated during the COVID-19 recovery phase. Most importantly

we found a set of 27 immune genes corresponding to a comparatively lower amount of SARS-CoV-2 specific antibodies

and identified two hub genes

IL1β

and

IL6

the protein expressions of which exhibited negative correlation with the immunoglobulin G (IgG) levels in COVID-19 convalescent sera. In addition

we found that high expressions of these 2 hub genes during the convalescent stage were negatively associated with the plasma cell marker CD138. Our study presented two key inflammatory factors correlated to the low level of SARS-CoV-2 specific antibodies

which indicated the potential regulatory process of plasmatic antibodies levels in some COVID-19 convalescent patients.

关键词

Keywords

AntibodiesConvalescent stageCOVID-19CytokinesIL1β and IL6

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

A peptide-based assay discriminates individual antibody response to SARS-CoV-2

COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment

Single-cell transcriptome landscape and antigen receptor dynamic during SARS-CoV-2 vaccination

Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight