Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma

Andrew T. Turk; Dario Garcia-Carracedo; David T. Kent; Elizabeth Philipone; Juana Maria Garcia-Pedrero; Salvatore M. Caruana; Lanny G. Close; Gloria H. Su

doi:10.1016/j.gendis.2020.12.002

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Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma

Full-length article | 更新时间：2022-06-24

- Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma
- Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma
- Genes & Diseases 2022年9卷第3期
- 作者机构：
  
  1. Department of Pathology and Cell Biology, and Columbia University,NY,New York,USA,10032
  2. Department of Otolaryngology, Columbia University,NY,New York,USA,10032
  3. Department of Otolaryngology, Vanderbilt University,TN,Nashville,USA,37232
  4. Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto Universitario de Oncología Del Principado de Asturias, Oviedo,Spain,33006
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.12.002
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-5-1，
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Andrew T. Turk, Dario Garcia-Carracedo, David T. Kent, 等. Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma[J]. Genes & Diseases, 2022,9(3).

Andrew T. Turk, Dario Garcia-Carracedo, David T. Kent, et al. Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma[J]. Genes & Diseases, 2022,9(3).
Andrew T. Turk, Dario Garcia-Carracedo, David T. Kent, 等. Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma[J]. Genes & Diseases, 2022,9(3). DOI： 10.1016/j.gendis.2020.12.002.

Andrew T. Turk, Dario Garcia-Carracedo, David T. Kent, et al. Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell carcinoma[J]. Genes & Diseases, 2022,9(3). DOI： 10.1016/j.gendis.2020.12.002.

摘要

Abstract

In order to assess Stathmin as an immunohistochemical (IHC) indicator of phosphatidylinositol 3-kinase (PI3K) pathway activity in HPV-negative head & neck squamous cell carcinoma (HNSCC)

we compared Stathmin IHC to expression of other pathway components. We also evaluated the relationship between Stathmin IHC and the mutational status of four key pathway genes. Finally

we ascertained whether Stathmin IHC correlates with tumor grade or primary site. Correlation exists between high Stathmin expression and high pAKT1 expression

indicating a role for Stathmin IHC as a marker of pathway activity. Our analysis did not show correlation between Stathmin IHC and mutation of the four genes evaluated. We also observed an association between high Stathmin expression and oropharyngeal primary site. Our results suggest utility of Stathmin IHC as an indicator of PI3K pathway activity

and thereby demonstrate potential relevance of Stathmin IHC in the context of HNSCC.

关键词

Keywords

CancerHead & neck squamous cell carcinomaPathologyStathmin

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