Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential

Bei Wang; Wen Xu; Chengyu Hu; Kai Liu; Jinlan Chen; Chong Guo; Chengfu Yuan

doi:10.1016/j.gendis.2020.11.016

您当前的位置：

首页 >

文章列表页 >

Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential

Review article | 更新时间：2022-06-24

- Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential
- Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential
- Genes & Diseases 2022年9卷第2期
- 作者机构：
  
  1. College of Medical Science, China Three Gorges University,Hubei,Yichang,PR China,443001
  2. College of Traditional Chinese Medicine, China Three Gorges University,Hubei,Yichang,PR China,443001
  3. Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University,Hubei,Yichang,PR China,443001
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.11.016
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-3-1，
扫描看全文
Bei Wang, Wen Xu, Chengyu Hu, 等. Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential[J]. Genes & Diseases, 2022,9(2).

Bei Wang, Wen Xu, Chengyu Hu, et al. Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential[J]. Genes & Diseases, 2022,9(2).
Bei Wang, Wen Xu, Chengyu Hu, 等. Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential[J]. Genes & Diseases, 2022,9(2). DOI： 10.1016/j.gendis.2020.11.016.

Bei Wang, Wen Xu, Chengyu Hu, et al. Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential[J]. Genes & Diseases, 2022,9(2). DOI： 10.1016/j.gendis.2020.11.016.

摘要

Abstract

The frequency of human suffering from cancer is increasing annually across the globe. This has fueled numerous investigations aimed at the prevention and cure of various cancers. Long non-coding RNA (lncRNA) are known to play a crucial role in cancer. For instance

cancer susceptibility candidate 11 (CASC11)

as one of the long non-coding RNAs

has been reported to be overexpressed in various tumors. This review elucidates the mechanism by which lncRNA CASC11 regulates tumors' biological processes and affirms its value as a therapeutic target for tumors. Through systematic analysis and review of relevant articles in PubMed

we revealed the pathophysiological mechanism of CASC11 on the tumor by regulating the biological processes of tumor such as proliferation

autophagy

apoptosis

thereby promoting tumor metastasis. We also revealed the regulatory pathways of CASC11 in different tumors

for instance by acting on a variety of microRNAs

oncogenic proteins

carcinogens

and transcription factors. Consequently

CASC11 regulates cancer proliferation

apoptosis

and invasion by altering the WNT/β-catenin signaling pathway and epithelial–mesenchymal transition (EMT). Furthermore

CASC11 expression has a high pertinence with clinical prognosis

suggesting that it is a potential marker for malignant tumors or a clinical adjuvant therapy in the future.

关键词

Keywords

CASC11Long non-coding RNAMalignant tumorsmicroRNATherapeutic targets

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

Clinical relevance of circulating non-coding RNAs in metabolic diseases: Emphasis on obesity, diabetes, cardiovascular diseases and metabolic syndrome

The role of autophagy in regulating metabolism in the tumor microenvironment

Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases

Microvesicles (MIVs) secreted from adipose-derived stem cells (ADSCs) contain multiple microRNAs and promote the migration and invasion of endothelial cells

Long noncoding RNAs (lncRNAs) in human lymphomas